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Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis.

Sathyamoorthy, T; Sandhu, G; Tezera, LB; Thomas, R; Singhania, A; Woelk, CH; Dimitrov, BD; Agranoff, D; Evans, CAW; Friedland, JS; et al. Sathyamoorthy, T; Sandhu, G; Tezera, LB; Thomas, R; Singhania, A; Woelk, CH; Dimitrov, BD; Agranoff, D; Evans, CAW; Friedland, JS; Elkington, PT (2015) Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis. PLoS One, 10 (1). e0117605. ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0117605
SGUL Authors: Friedland, Jonathan Samuel

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Abstract

Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p<0.001), not being elevated in symptomatic controls (symptoms suspicious of TB but active disease excluded). Plasma MMP-8 concentrations inversely correlated with body mass index. Plasma MMP-8 concentration was 1.51-fold higher in males than females with TB (p<0.05) and this difference was not due to greater disease severity in men. Gender-specific analysis of MMPs demonstrated consistent increase in MMP-1 and -8 in TB, but MMP-8 was a better discriminator for TB in men. Plasma collagenases are elevated in pulmonary TB and differ between men and women. Gender must be considered in investigation of TB immunopathology and development of novel diagnostic markers.

Item Type: Article
Additional Information: © 2015 Sathyamoorthy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Keywords: Adult, Body Mass Index, Case-Control Studies, Female, Humans, Male, Matrix Metalloproteinase 1, Matrix Metalloproteinase 8, Middle Aged, Multivariate Analysis, Neutrophils, Principal Component Analysis, Sex Characteristics, Tuberculosis, Pulmonary, Up-Regulation, Young Adult, Neutrophils, Humans, Tuberculosis, Pulmonary, Body Mass Index, Multivariate Analysis, Case-Control Studies, Up-Regulation, Sex Characteristics, Principal Component Analysis, Adult, Middle Aged, Female, Male, Matrix Metalloproteinase 1, Matrix Metalloproteinase 8, Young Adult, Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, COMMUNITY-ACQUIRED PNEUMONIA, TISSUE INHIBITORS, GENE-EXPRESSION, MATRIX-METALLOPROTEINASE-9, DISEASE, PROTEIN, TRANSMISSION, SEVERITY, LEVEL, CELLS, MD Multidisciplinary, General Science & Technology
Journal or Publication Title: PLoS One
ISSN: 1932-6203
Language: eng
Dates:
DateEvent
30 January 2015Published
29 December 2014Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
G0900429Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/K007467/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIEDWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 25635689
Web of Science ID: WOS:000350680700091
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110616
Publisher's version: https://doi.org/10.1371/journal.pone.0117605

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