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Nicorandil and Long-acting Nitrates: Vasodilator Therapies for the Management of Chronic Stable Angina Pectoris.

Tarkin, JM; Kaski, JC (2018) Nicorandil and Long-acting Nitrates: Vasodilator Therapies for the Management of Chronic Stable Angina Pectoris. Eur Cardiol, 13 (1). pp. 23-28. ISSN 1758-3764 https://doi.org/10.15420/ecr.2018.9.2
SGUL Authors: Kaski, Juan Carlos

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Abstract

Nicorandil and long-acting nitrates are vasodilatory drugs used commonly in the management of chronic stable angina pectoris. Both nicorandil and long-acting nitrates exert anti-angina properties via activation of nitric oxide (NO) signalling pathways, triggering vascular smooth muscle cell relaxation. Nicorandil has additional actions as an arterial K+ATP channel agonist, resulting in more "balanced" arterial and venous vasodilatation than nitrates. Ultimately, these drugs prevent angina symptoms through reductions in preload and diastolic wall tension and, to a lesser extent, epicardial coronary artery dilatation and lowering of systemic blood pressure. While there is some evidence to suggest a modest reduction in cardiovascular events among patients with stable angina treated with nicorandil compared to placebo, this prognostic benefit has yet to be proven conclusively. In contrast, there is emerging evidence to suggest that chronic use of long-acting nitrates might cause endothelial dysfunction and increased cardiovascular risk in some patients.

Item Type: Article
Keywords: Nicorandil, coronary artery disease, long-acting nitrates, stable angina, vasodilators, Nicorandil, long-acting nitrates, vasodilators, stable angina, coronary artery disease, Nicorandil, coronary artery disease, long-acting nitrates, stable angina, vasodilators
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Eur Cardiol
ISSN: 1758-3764
Language: eng
Dates:
DateEvent
August 2018Published
6 July 2018Accepted
PubMed ID: 30310466
Web of Science ID: WOS:000447120900005
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110491
Publisher's version: https://doi.org/10.15420/ecr.2018.9.2

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