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Setting Eyes on the Retinal Pigment Epithelium.

Moreno-Marmol, T; Cavodeassi, F; Bovolenta, P (2018) Setting Eyes on the Retinal Pigment Epithelium. Front Cell Dev Biol, 6. p. 145. ISSN 2296-634X https://doi.org/10.3389/fcell.2018.00145
SGUL Authors: Cavodeassi, Florencia

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Abstract

The neural component of the zebrafish eye derives from a small group of cells known as the eye/retinal field. These cells, positioned in the anterior neural plate, rearrange extensively and generate the optic vesicles (OVs). Each vesicle subsequently folds over itself to form the double-layered optic cup, from which the mature eye derives. During this transition, cells of the OV are progressively specified toward three different fates: the retinal pigment epithelium (RPE), the neural retina, and the optic stalk. Recent studies have shown that folding of the zebrafish OV into a cup is in part driven by basal constriction of the cells of the future neural retina. During folding, however, RPE cells undergo an even more dramatic shape conversion that seems to entail the acquisition of unique properties. How these changes occur and whether they contribute to optic cup formation is still poorly understood. Here we will review present knowledge on RPE morphogenesis and discuss potential mechanisms that may explain such transformation using examples taken from embryonic Drosophila tissues that undergo similar shape changes. We will also put forward a hypothesis for optic cup folding that considers an active contribution from the RPE.

Item Type: Article
Additional Information: Copyright © 2018 Moreno-Marmol, Cavodeassi and Bovolenta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: eye development, morphogenesis, optic cup, squamous epithelial cell, zebrafish (Danio rerio)
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: Front Cell Dev Biol
ISSN: 2296-634X
Language: eng
Dates:
DateEvent
24 October 2018Published
8 October 2018Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 30406103
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110403
Publisher's version: https://doi.org/10.3389/fcell.2018.00145

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