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Trends in congenital anomalies in Europe from 1980 to 2012.

Morris, JK; Springett, AL; Greenlees, R; Loane, M; Addor, M-C; Arriola, L; Barisic, I; Bergman, JEH; Csaky-Szunyogh, M; Dias, C; et al. Morris, JK; Springett, AL; Greenlees, R; Loane, M; Addor, M-C; Arriola, L; Barisic, I; Bergman, JEH; Csaky-Szunyogh, M; Dias, C; Draper, ES; Garne, E; Gatt, M; Khoshnood, B; Klungsoyr, K; Lynch, C; McDonnell, R; Nelen, V; Neville, AJ; O'Mahony, M; Pierini, A; Queisser-Luft, A; Randrianaivo, H; Rankin, J; Rissmann, A; Kurinczuk, J; Tucker, D; Verellen-Dumoulin, C; Wellesley, D; Dolk, H (2018) Trends in congenital anomalies in Europe from 1980 to 2012. PLoS One, 13 (4). e0194986. ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0194986
SGUL Authors: Morris, Joan Katherine

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Abstract

BACKGROUND: Surveillance of congenital anomalies is important to identify potential teratogens. METHODS: This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models. RESULTS: Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing. CONCLUSIONS: The annual increasing prevalence of severe congenital heart defects, single ventricle, atrioventricular septal defects and tetralogy of Fallot of 1.4% (95% CI: 0.7% to 2.0%), 4.6% (1.0% to 8.2%), 3.4% (1.3% to 5.5%) and 4.1% (2.4% to 5.7%) respectively may reflect increases in maternal obesity and diabetes (known risk factors). The increased prevalence of cystic adenomatous malformation of the lung [6.5% (3.5% to 9.4%)] and decreased prevalence of limb reduction defects [-2.8% (-4.2% to -1.5%)] are unexplained. For renal dysplasia and maternal infections, increasing trends may be explained by increased screening, and deceases in patent ductus arteriosus at term and increases in craniosynostosis, by improved follow up period after birth and improved diagnosis. For oesophageal atresia, duodenal atresia/stenosis and ano-rectal atresia/stenosis recent changes in prevalence appeared incidental when compared with larger long term fluctuations. For microcephaly and congenital hydronephrosis trends could not be interpreted due to discrepancies in diagnostic criteria. The trends for club foot and syndactyly disappeared once registries with disparate results were excluded. No decrease in neural tube defects was detected, despite efforts at prevention through folic acid supplementation.

Item Type: Article
Additional Information: © 2018 Morris et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Congenital Abnormalities, Europe, Female, History, 20th Century, History, 21st Century, Humans, Male, Population Surveillance, Pregnancy, Prevalence, Registries, Humans, Population Surveillance, Registries, Prevalence, Pregnancy, History, 20th Century, History, 21st Century, Europe, Female, Male, Congenital Abnormalities, MD Multidisciplinary, General Science & Technology
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: PLoS One
ISSN: 1932-6203
Language: eng
Dates:
DateEvent
5 April 2018Published
14 March 2018Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 29621304
Web of Science ID: WOS:000429206800031
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110347
Publisher's version: https://doi.org/10.1371/journal.pone.0194986

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