SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Molecular assays for antimalarial drug resistance surveillance: A target product profile.

Nsanzabana, C; Ariey, F; Beck, H-P; Ding, XC; Kamau, E; Krishna, S; Legrand, E; Lucchi, N; Miotto, O; Nag, S; et al. Nsanzabana, C; Ariey, F; Beck, H-P; Ding, XC; Kamau, E; Krishna, S; Legrand, E; Lucchi, N; Miotto, O; Nag, S; Noedl, H; Roper, C; Rosenthal, PJ; Schallig, HDFH; Taylor, SM; Volkman, SK; Gonzalez, IJ (2018) Molecular assays for antimalarial drug resistance surveillance: A target product profile. PLoS One, 13 (9). e0204347. ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0204347
SGUL Authors: Krishna, Sanjeev

[img]
Preview
PDF Published Version
Available under License Creative Commons Public Domain Dedication.

Download (993kB) | Preview

Abstract

Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with artemisinin derivatives has now spread in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination therapies are expected to be available in the near future. There is a need to strengthen surveillance systems for early detection and response to the antimalarial drug resistance threat. Current surveillance is mainly done through therapeutic efficacy studies; however these studies are complex and both time- and resource-intensive. For multiple common antimalarials, parasite drug resistance has been correlated with specific genetic mutations, and the molecular markers associated with antimalarial drug resistance offer a simple and powerful tool to monitor the emergence and spread of resistant parasites. Different techniques to analyse molecular markers associated with antimalarial drug resistance are available, each with advantages and disadvantages. However, procedures are not adequately harmonized to facilitate comparisons between sites. Here we describe the target product profiles for tests to analyse molecular markers associated with antimalarial drug resistance, discuss how use of current techniques can be standardised, and identify the requirements for an ideal product that would allow malaria endemic countries to provide useful spatial and temporal information on the spread of resistance.

Item Type: Article
Additional Information: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Keywords: MD Multidisciplinary, General Science & Technology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: PLoS One
ISSN: 1932-6203
Language: eng
Dates:
DateEvent
20 September 2018Published
5 September 2018Accepted
Publisher License: Creative Commons: Public Domain Dedication
Projects:
Project IDFunderFunder ID
UNSPECIFIEDDepartment of Foreign Affairs and Trade, Australian Governmenthttp://dx.doi.org/10.13039/501100000996
PubMed ID: 30235327
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110200
Publisher's version: https://doi.org/10.1371/journal.pone.0204347

Actions (login required)

Edit Item Edit Item