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The somatic proteins of Toxocara canis larvae and excretory-secretory products revealed by proteomics.

da Silva, MB; Urrego A, JR; Oviedo, Y; Cooper, PJ; Pacheco, LGC; Pinheiro, CS; Ferreira, F; Briza, P; Alcantara-Neves, NM (2018) The somatic proteins of Toxocara canis larvae and excretory-secretory products revealed by proteomics. Vet Parasitol, 259. pp. 25-34. ISSN 1873-2550 https://doi.org/10.1016/j.vetpar.2018.06.015
SGUL Authors: Cooper, Philip John

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Abstract

Toxocariasis is a widespread helminth infection of dogs and cats, caused by Toxocara canis and Toxocara cati larvae, respectively. Toxocara spp. can cause zoonotic infections in humans by invading tissues and organs causing pathology. Toxocara spp. larvae release excretory-secretory molecules (TES) into the body of their host that are fundamental to the host-parasite interaction and could be used as targets for novel diagnostics and vaccines. In the present study, we identified 646 T. canis proteins from TES and larval extract using 1D-SDS PAGE followed by mass spectrometry. A wide range of proteins was identified that may play a role both in the induction of the host immune response and host pathology, and in parasite metabolism and survival. Among these proteins there are potential candidates for novel diagnostics and vaccines for dogs and cats toxocariases.

Item Type: Article
Additional Information: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Excretory/secretory proteins, Larvae, Proteomics, Toxocara canis, Toxocariasis, Excretory/secretory proteins, Larvae, Proteomics, Toxocara canis, Toxocariasis, Mycology & Parasitology, 0605 Microbiology, 0704 Fisheries Sciences, 0707 Veterinary Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Vet Parasitol
ISSN: 1873-2550
Language: eng
Dates:
DateEvent
15 August 2018Published
26 June 2018Published Online
23 June 2018Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
077/2012Coordination for the Improvement of Higher Education PersonnelUNSPECIFIED
PubMed ID: 30056980
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110113
Publisher's version: https://doi.org/10.1016/j.vetpar.2018.06.015

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