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Scutoids are a geometrical solution to three-dimensional packing of epithelia.

Gómez-Gálvez, P; Vicente-Munuera, P; Tagua, A; Forja, C; Castro, AM; Letrán, M; Valencia-Expósito, A; Grima, C; Bermúdez-Gallardo, M; Serrano-Pérez-Higueras, Ó; et al. Gómez-Gálvez, P; Vicente-Munuera, P; Tagua, A; Forja, C; Castro, AM; Letrán, M; Valencia-Expósito, A; Grima, C; Bermúdez-Gallardo, M; Serrano-Pérez-Higueras, Ó; Cavodeassi, F; Sotillos, S; Martín-Bermudo, MD; Márquez, A; Buceta, J; Escudero, LM (2018) Scutoids are a geometrical solution to three-dimensional packing of epithelia. Nat Commun, 9 (1). p. 2960. ISSN 2041-1723 https://doi.org/10.1038/s41467-018-05376-1
SGUL Authors: Cavodeassi, Florencia

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Abstract

As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term "scutoid". The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs.

Item Type: Article
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2018
Keywords: MD Multidisciplinary
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: Nat Commun
ISSN: 2041-1723
Language: eng
Dates:
DateEvent
27 July 2018Published
11 June 2018Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
BFU2016-74975-PMinisterio de Economía y Competitividad (Ministry of Economy and Competitiveness)UNSPECIFIED
BFU2016-76528-PMinisterio de Economía y Competitividad (Ministry of Economy and Competitiveness)UNSPECIFIED
BFU2014-55918Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness)UNSPECIFIED
BFU2016-80797Ministerio de Ciencia y Tecnología (Ministry of Science and Technology)UNSPECIFIED
PubMed ID: 30054479
Web of Science ID: WOS:000439971400001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110060
Publisher's version: https://doi.org/10.1038/s41467-018-05376-1

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