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Adiposity in early, middle and later adult life and cardiometabolic risk markers in later life; findings from the British regional heart study.

Kapetanakis, VV; Rudnicka, AR; Wathern, AK; Lennon, L; Papacosta, O; Cook, DG; Wannamethee, SG; Whincup, PH; Owen, CG (2014) Adiposity in early, middle and later adult life and cardiometabolic risk markers in later life; findings from the British regional heart study. PLoS One, 9 (12). e114289. ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0114289
SGUL Authors: Cook, Derek Gordon Owen, Christopher Grant Rudnicka, Alicja Regina Whincup, Peter Hynes Wathern, Andrea Karen

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Abstract

OBJECTIVES: This research investigates the associations between body mass index (BMI) at 21, 40-59, 60-79 years of age on cardiometabolic risk markers at 60-79 years. METHODS: A prospective study of 3464 British men with BMI measured at 40-59 and 60-79 years, when cardiometabolic risk was assessed. BMI at 21 years was ascertained from military records, or recalled from middle-age (adjusted for reporting bias); associations between BMI at different ages and later cardiometabolic risk markers were examined using linear regression. Sensitive period, accumulation and mobility life course models were devised for high BMI (defined as BMI≥75th centile) and compared with a saturated BMI trajectory model. RESULTS: At ages 21, 40-59 and 60-79 years, prevalences of overweight (BMI≥25 kg/m2) were 12%, 53%, 70%, and obesity (≥30 kg/m2) 1.6%, 6.6%, and 17.6%, respectively. BMI at 21 years was positively associated with serum insulin, blood glucose, and HbA1c at 60-79 years, with increases of 1.5% (95%CI 0.8,2.3%), 0.4% (0.1,0.6%), 0.3% (0.1,0.4%) per 1 kg/m2, respectively, but showed no associations with blood pressure or blood cholesterol. However, these associations were modest compared to those between BMI at 60-79 years and serum insulin, blood glucose and HbA1c at 60-79 years, with increases of 8.6% (8.0,9.2%), 0.7% (0.5,0.9%), and 0.5% (0.4,0.7%) per 1 kg/m2, respectively. BMI at 60-79 years was also associated with total cholesterol and blood pressure. Associations for BMI at 40-59 years were mainly consistent with those of BMI at 60-79 years. None of the life course models fitted the data as well as the saturated model for serum insulin. A sensitive period at 50 years for glucose and HbA1c and sensitive period at 70 years for blood pressure were identified. CONCLUSIONS: In this cohort of men who were thin compared to more contemporary cohorts, BMI in later life was the dominant influence on cardiovascular and diabetes risk. BMI in early adult life may have a small long-term effect on diabetes risk.

Item Type: Article
Additional Information: © 2014 Kapetanakis et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Adiposity, Adult, Aged, Blood Glucose, Body Mass Index, Cardiovascular Diseases, Glycated Hemoglobin A, Humans, Male, Middle Aged, Obesity, Overweight, Risk Factors, Waist Circumference, Humans, Cardiovascular Diseases, Obesity, Hemoglobin A, Glycosylated, Blood Glucose, Body Mass Index, Risk Factors, Adult, Aged, Middle Aged, Male, Adiposity, Overweight, Waist Circumference, General Science & Technology, MD Multidisciplinary
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: PLoS One
ISSN: 1932-6203
Language: eng
Dates:
DateEvent
4 December 2014Published
7 November 2014Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
RG/13/16/30528British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PG/10/030/28330British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
RG/08/013/25942British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PubMed ID: 25474626
Web of Science ID: WOS:000346382500010
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109983
Publisher's version: https://doi.org/10.1371/journal.pone.0114289

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