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Epidemiology of infections and antimicrobial use in Greek Neonatal Units.

Gkentzi, D; Kortsalioudaki, C; Cailes, BC; Zaoutis, T; Kopsidas, J; Tsolia, M; Spyridis, N; Siahanidou, S; Sarafidis, K; Heath, PT; et al. Gkentzi, D; Kortsalioudaki, C; Cailes, BC; Zaoutis, T; Kopsidas, J; Tsolia, M; Spyridis, N; Siahanidou, S; Sarafidis, K; Heath, PT; Dimitriou, G; Neonatal Infection Surveillance Network in Greece (2019) Epidemiology of infections and antimicrobial use in Greek Neonatal Units. Arch Dis Child Fetal Neonatal Ed, 104 (3). F293-F297. ISSN 1468-2052 https://doi.org/10.1136/archdischild-2018-315024
SGUL Authors: Heath, Paul Trafford

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Abstract

OBJECTIVE: To describe the epidemiology of neonatal infections and of antimicrobial use in Greek Neonatal Units (NNUs) in order to develop national, evidence-based guidelines on empiric antimicrobial use for neonatal sepsis in Greece. DESIGN: Retrospective analysis of prospectively collected infection surveillance data from 2012 to 2015, together with a Point Prevalence Survey (PPS) on antimicrobial use and the collection of data on local empiric antimicrobial policies. SETTING: 16 NNUs in Greece participating in the neonIN infection surveillance network PATIENTS: Newborns in participating NNUs who had a positive blood, cerebrospinal fluid or urine culture and were treated with at least 5 days of antibiotics. RESULTS: 459 episodes were recorded in 418 infants. The overall incidence of infection was 50/1000 NNU-admissions. The majority of episodes were late-onset sepsis (LOS) (413, 90%). Coagulase-negative Staphylococci (80%) were the most common Gram-positive organisms causing LOS and Klebsiella spp (39%) the most common Gram-negative. Nearly half (45%) of the Klebsiella spp were resistant to at least one aminoglycoside. The PPS revealed that 196 of 484 (40%) neonates were on antimicrobials. The survey revealed wide variation in empiric antimicrobial policies for LOS. CONCLUSIONS: This is the largest collection of data on the epidemiology of neonatal infections in Greece and on neonatal antimicrobial use. It provides the background for the development of national evidence-based guidelines. Continuous surveillance, the introduction of antimicrobial stewardship interventions and evidence-based guidelines are urgently required.

Item Type: Article
Additional Information: This article has been accepted for publication in ADC Fetal & Neonatal edition following peer review. The definitive copyedited, typeset version Gkentzi D, Kortsalioudaki C, Cailes BC on behalf of the Neonatal Infection Surveillance Network in Greece, et al Epidemiology of infections and antimicrobial use in Greek Neonatal Units Archives of Disease in Childhood - Fetal and Neonatal Edition 2019;104:F293-F297 is available online at: http://dx.doi.org/10.1136/archdischild-2018-315024
Keywords: antimicrobial use, epidemiology, greece, neonatal infections, antimicrobial use, epidemiology, greece, neonatal infections, Pediatrics, 1114 Paediatrics And Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Arch Dis Child Fetal Neonatal Ed
ISSN: 1468-2052
Language: eng
Dates:
DateEvent
29 April 2019Published
28 June 2018Published Online
9 June 2018Accepted
Publisher License: Publisher's own licence
PubMed ID: 29954881
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109966
Publisher's version: https://doi.org/10.1136/archdischild-2018-315024

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