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Demographics, treatment and outcomes of atrial fibrillation in a developing country: the population-based TuRkish Atrial Fibrillation (TRAF) cohort.

Yavuz, B; Ata, N; Oto, E; Katircioglu-Öztürk, D; Aytemir, K; Evranos, B; Koselerli, R; Ertugay, E; Burkan, A; Ertugay, E; et al. Yavuz, B; Ata, N; Oto, E; Katircioglu-Öztürk, D; Aytemir, K; Evranos, B; Koselerli, R; Ertugay, E; Burkan, A; Ertugay, E; Gale, CP; Camm, AJ; Oto, A (2017) Demographics, treatment and outcomes of atrial fibrillation in a developing country: the population-based TuRkish Atrial Fibrillation (TRAF) cohort. Europace, 19 (5). pp. 734-740. ISSN 1532-2092 https://doi.org/10.1093/europace/euw385
SGUL Authors: Camm, Alan John

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Abstract

Aims: Although atrial fibrillation (AF) is increasingly common in developed countries, there is limited information regarding its demographics, co-morbidities, treatments and outcomes in the developing countries. We present the profile of the TuRkish Atrial Fibrillation (TRAF) cohort which provides real-life data about prevalence, incidence, co-morbidities, treatment, healthcare utilization and outcomes associated with AF. Methods and results: The TRAF cohort was extracted from MEDULA, a health insurance database linking hospitals, general practitioners, pharmacies and outpatient clinics for almost 100% of the inhabitants of the country. The cohort includes 507 136 individuals with AF between 2008 and 2012 aged >18 years who survived the first 30 days following diagnosis. Of 507 136 subjects, there were 423 109 (83.4%) with non-valvular AF and 84 027 (16.6%) with valvular AF. The prevalence was 0.80% in non-valvular AF and 0.28% in valvular AF; in 2012 the incidence of non-valvular AF (0.17%) was higher than valvular AF (0.04%). All-cause mortality was 19.19% (97 368) and 11.47% (58 161) at 1-year after diagnosis of AF. There were 35 707 (7.04%) ischaemic stroke/TIA/thromboembolism at baseline and 34 871 (6.87%) during follow-up; 11 472 (2.26%) major haemorrhages at baseline and 10 183 (2.01%) during follow-up, and 44 116 (8.69%) hospitalizations during the follow-up. Conclusion: The TRAF cohort is the first population-based, whole-country cohort of AF epidemiology, quality of care and outcomes. It provides a unique opportunity to study the patterns, causes and impact of treatments on the incidence and outcomes of AF in a developing country.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in EP-Europace following peer review. The version of record Bünyamin Yavuz, Naim Ata, Emre Oto, Deniz Katircioglu-Öztürk, Kudret Aytemir, Banu Evranos, Rasim Koselerli, Emre Ertugay, Abdulkadir Burkan, Emrah Ertugay, Christ P Gale, A. John Camm, Ali Oto; Demographics, treatment and outcomes of atrial fibrillation in a developing country: the population-based TuRkish Atrial Fibrillation (TRAF) cohort, EP Europace, Volume 19, Issue 5, 1 May 2017, Pages 734–740 is available online at: https://doi.org/10.1093/europace/euw385
Keywords: Atrial fibrillation, CHA2DS2Vasc, Incidence of atrial fibrillation, Population-based cohort, Atrial fibrillation, Incidence of atrial fibrillation, CHA(2)DS(2)Vasc, Population-based cohort, Atrial fibrillation, CHA2DS2Vasc, Incidence of atrial fibrillation, Population-based cohort, Cardiovascular System & Hematology, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: Europace
ISSN: 1532-2092
Language: eng
Dates:
DateEvent
1 May 2017Published
10 February 2017Published Online
14 December 2016Accepted
PubMed ID: 28186565
Web of Science ID: WOS:000404444200009
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109571
Publisher's version: https://doi.org/10.1093/europace/euw385

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