SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Translating Autoimmune Pathogenesis into Targeted Therapies for Systemic Sclerosis

Russell, M; Sofat, N (2017) Translating Autoimmune Pathogenesis into Targeted Therapies for Systemic Sclerosis. In: Immunopathogenesis and Immune-based Therapy for Selected Autoimmune Disorders. (ed Aridi, Mourad.) InTech. DOI: https://doi.org/10.5772/63032
SGUL Authors: Sofat, Nidhi

[img]
Preview
PDF Published Version
Available under License Creative Commons Attribution.

Download (3MB) | Preview

Abstract

Targeted therapies including tumour necrosis factor α (TNFα) inhibitors have transformed the management of a number of autoimmune conditions over the past 20 years. One autoimmune rheumatological condition with significant potential for the development of targeted therapies is systemic sclerosis (SSc). In this chapter, we use SSc as an example of how research into the pathogenic processes underlying autoimmune conditions can be translated into novel targeted therapies. We review the evidence base for a range of targeted therapies for SSc identified from a systematic literature search, before highlighting a number of studies currently underway. Keywords: systemic sclerosis, scleroderma, targeted therapies, biological therapy, biologic, rheumatology, rheumatoid arthritis, autoimmune

Item Type: Book Section
Additional Information: © 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Editors: Aridi, Mourad
ISBN: 978-953-51-3022-2, 978-953-51-3021-5
Dates:
DateEvent
22 March 2017Published
Publisher License: Creative Commons: Attribution 3.0
URI: https://openaccess.sgul.ac.uk/id/eprint/109555
Publisher's version: https://doi.org/10.5772/63032

Actions (login required)

Edit Item Edit Item