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Language ability in preterm children is associated with arcuate fasciculi microstructure at term.

Salvan, P; Tournier, JD; Batalle, D; Falconer, S; Chew, A; Kennea, N; Aljabar, P; Dehaene-Lambertz, G; Arichi, T; Edwards, AD; et al. Salvan, P; Tournier, JD; Batalle, D; Falconer, S; Chew, A; Kennea, N; Aljabar, P; Dehaene-Lambertz, G; Arichi, T; Edwards, AD; Counsell, SJ (2017) Language ability in preterm children is associated with arcuate fasciculi microstructure at term. Hum Brain Mapp, 38 (8). pp. 3836-3847. ISSN 1097-0193 https://doi.org/10.1002/hbm.23632
SGUL Authors: Kennea, Nigel

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Abstract

In the mature human brain, the arcuate fasciculus mediates verbal working memory, word learning, and sublexical speech repetition. However, its contribution to early language acquisition remains unclear. In this work, we aimed to evaluate the role of the direct segments of the arcuate fasciculi in the early acquisition of linguistic function. We imaged a cohort of 43 preterm born infants (median age at birth of 30 gestational weeks; median age at scan of 42 postmenstrual weeks) using high b value high-angular resolution diffusion-weighted neuroimaging and assessed their linguistic performance at 2 years of age. Using constrained spherical deconvolution tractography, we virtually dissected the arcuate fasciculi and measured fractional anisotropy (FA) as a metric of white matter development. We found that term equivalent FA of the left and right arcuate fasciculi was significantly associated with individual differences in linguistic and cognitive abilities in early childhood, independent of the degree of prematurity. These findings suggest that differences in arcuate fasciculi microstructure at the time of normal birth have a significant impact on language development and modulate the first stages of language learning. Hum Brain Mapp 38:3836-3847, 2017. © 2017 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: © 2017 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: brain, diffusion magnetic resonance imaging, infant, language development, preterm birth, diffusion magnetic resonance imaging, infant, language development, brain, preterm birth, Experimental Psychology, 1109 Neurosciences, 1702 Cognitive Science
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Hum Brain Mapp
ISSN: 1097-0193
Language: eng
Dates:
DateEvent
5 July 2017Published
4 May 2017Published Online
17 April 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
RP-PG-0707-10154National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
MR/K006355/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/L011530/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
PubMed ID: 28470961
Web of Science ID: WOS:000404963900006
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109269
Publisher's version: https://doi.org/10.1002/hbm.23632

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