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Association between Systemic Lupus Erythematosus and Peridontitis: A Systematic Review and Meta-Analysis

Rutter-Locher, Z; Smith, TO; Giles, I; Sofat, N (2017) Association between Systemic Lupus Erythematosus and Peridontitis: A Systematic Review and Meta-Analysis. Frontiers in Immunology, 8 (1295). ISSN 1664-3224 https://doi.org/10.3389/fimmu.2017.01295
SGUL Authors: Sofat, Nidhi

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Abstract

Background: Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory autoimmune disease, the etiology of which remains only partially characterized. Strong evidence implicates chronic infections in the development and chronicity of autoimmune conditions. Recently, an association has been demonstrated between periodontitis and rheumatoid arthritis. Such observations have led to the investigation of the possible role of periodontitis and oral dysbiosis in other systemic inflammatory conditions, including SLE. The aim of this study was to examine whether there is an association between SLE and periodontitis. Methods: MEDLINE via OVID, EMBASE via OVID, and PsycINFO via OVID databases were searched to identify eligible studies, screened by two independent authors and verified by a third. Studies comparing presence of periodontitis in SLE cases to controls without SLE were included. Data were extracted using a predefined table and papers were appraised using Down’s and Black tool. Mantel–Haenszel meta-analysis was performed using RevMan. Results: Eight case–control studies were included, with 487 SLE cases and a total of 1,383 participants. On meta-analysis of four studies, risk of periodontitis in SLE cases compared to controls was significantly greater with a risk ratio of 1.76 (95% CI 1.29–2.41, p = 0.0004). No statistical difference was found in individual measures of periodontitis, such as probing depth or clinical attachment loss, between SLE cases and controls. Conclusion: Our study found a statistically significant increased risk of periodontitis in patients with SLE compared to controls. This finding suggests a possible association between these two conditions. Larger longitudinal studies are needed to confirm this possible association.

Item Type: Article
Additional Information: Copyright: © 2017 Rutter-Locher, Smith, Giles and Sofat. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Frontiers in Immunology
ISSN: 1664-3224
Dates:
DateEvent
17 October 2017Published Online
27 September 2017Accepted
Projects:
Project IDFunderFunder ID
NIHR Academic Clinical FellowshipResearch Trainees Coordinating Centrehttp://dx.doi.org/10.13039/501100000659
URI: https://openaccess.sgul.ac.uk/id/eprint/109235
Publisher's version: https://doi.org/10.3389/fimmu.2017.01295

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