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The independence of the infundibular building blocks in the setting of double-outlet right ventricle.

Aiello, VD; Spicer, DE; Anderson, RH; Brown, NA; Mohun, TJ (2017) The independence of the infundibular building blocks in the setting of double-outlet right ventricle. Cardiol Young, 27 (5). pp. 825-836. ISSN 1467-1107
SGUL Authors: Brown, Nigel Andrew

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It has long been contentious as to whether the presence of bilateral infundibulums, or conuses, is a prerequisite for the diagnosis of double-outlet right ventricle. As the use of such a criterion would abrogate the so-called "morphological method", which correctly states that one variable entity should not be defined on the basis of another entity that is itself variable, it is now accepted that double outlet can exist in the setting of fibrous continuity between the leaflets of the atrioventricular and arterial valves. Although this debate has now been resolved, there are other contentious areas still requiring clarification in the setting of hearts unified because of the presence of this particular ventriculo-arterial connection - for example, it is questionable whether the channel between the ventricles should be described as a "ventricular septal defect", whereas it is equally arguable that the mere presence of fibrous continuity between the leaflets of the arterial valves does not necessarily place the channel in a doubly committed location. In this review, we describe a series of autopsied hearts in which the anatomical features serve to illuminate these various topics. We then discuss recent findings regarding cardiac development that point to the individuality of the building blocks of the ventricular outflow tracts, specifically the outlet septum, the inner heart curvature, or ventriculo-infundibular fold, and the septomarginal trabeculation, or septal band.

Item Type: Article
Additional Information: © Cambridge University Press, 2017. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (, which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Outlet septum, inner heart curvature, septal band, septomarginal trabeculation, ventriculo-infundibular fold, Outlet septum, septomarginal trabeculation, inner heart curvature, septal band, ventriculo-infundibular fold, Cardiovascular System & Hematology, 1102 Cardiovascular Medicine And Haematology
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Journal or Publication Title: Cardiol Young
ISSN: 1467-1107
Language: eng
July 2017Published
27 March 2017Published Online
13 February 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 28555539
Web of Science ID: WOS:000402408300001
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