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Body composition at birth and its relationship with neonatal anthropometric ratios: the newborn body composition study of the INTERGROWTH-21(st) project.

Villar, J; Puglia, FA; Fenton, TR; Cheikh Ismail, L; Staines-Urias, E; Giuliani, F; Ohuma, EO; Victora, CG; Sullivan, P; Barros, FC; et al. Villar, J; Puglia, FA; Fenton, TR; Cheikh Ismail, L; Staines-Urias, E; Giuliani, F; Ohuma, EO; Victora, CG; Sullivan, P; Barros, FC; Lambert, A; Papageorghiou, AT; Ochieng, R; Jaffer, YA; Altman, DG; Noble, AJ; Gravett, MG; Purwar, M; Pang, R; Uauy, R; Kennedy, SH; Bhutta, ZA (2017) Body composition at birth and its relationship with neonatal anthropometric ratios: the newborn body composition study of the INTERGROWTH-21(st) project. Pediatr Res, 82 (2). pp. 305-316. ISSN 1530-0447 https://doi.org/10.1038/pr.2017.52
SGUL Authors: Papageorghiou, Aris

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Abstract

Background We aimed to describe newborn body composition and identify which anthropometric ratio (weight/length; BMI; or ponderal index, PI) best predicts fat mass (FM) and fat-free mass (FFM). Methods Air-displacement plethysmography (PEA POD) was used to estimate FM, FFM, and body fat percentage (BF%). Associations between FFM, FM, and BF% and weight/length, BMI, and PI were evaluated in 1,019 newborns using multivariate regression analysis. Charts for FM, FFM, and BF% were generated using a prescriptive subsample (n=247). Standards for the best-predicting anthropometric ratio were calculated utilizing the same population used for the INTERGROWTH-21(st) Newborn Size Standards (n=20,479). Results FFM and FM increased consistently during late pregnancy. Differential FM, BF%, and FFM patterns were observed for those born preterm (34(+0)-36(+6) weeks' gestation) and with impaired intrauterine growth. Weight/length by gestational age (GA) was a better predictor of FFM and FM (adjusted R(2)=0.92 and 0.71, respectively) than BMI or PI, independent of sex, GA, and timing of measurement. Results were almost identical when only preterm newborns were studied. We present sex-specific centiles for weight/length ratio for GA. Conclusions Weight/length best predicts newborn FFM and FM. There are differential FM, FFM, and BF% patterns by sex, GA, and size at birth.

Item Type: Article
Additional Information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ © The Author(s) (2017)
Keywords: Pediatrics, 1114 Paediatrics And Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Pediatr Res
ISSN: 1530-0447
Language: eng
Dates:
DateEvent
August 2017Published
31 May 2017Published Online
17 February 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
49038Bill and Melinda Gates Foundationhttp://dx.doi.org/10.13039/100000865
PubMed ID: 28445454
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109165
Publisher's version: https://doi.org/10.1038/pr.2017.52

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