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St George's Respiratory Questionnaire Score Predicts Outcomes in Patients with COPD: Analysis of Individual Patient Data in the COPD Biomarkers Qualification Consortium Database.

Müllerova, H; Gelhorn, H; Wilson, H; Benson, VS; Karlsson, N; Menjoge, S; Rennard, SI; Tabberer, M; Tal-Singer, R; Merrill, D; et al. Müllerova, H; Gelhorn, H; Wilson, H; Benson, VS; Karlsson, N; Menjoge, S; Rennard, SI; Tabberer, M; Tal-Singer, R; Merrill, D; Jones, PW (2017) St George's Respiratory Questionnaire Score Predicts Outcomes in Patients with COPD: Analysis of Individual Patient Data in the COPD Biomarkers Qualification Consortium Database. Chronic Obstr Pulm Dis, 4 (2). pp. 141-149. ISSN 2372-952X https://doi.org/10.15326/jcopdf.4.2.2017.0131
SGUL Authors: Jones, Paul Wyatt

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Abstract

Background: We aimed to estimate the usefulness of a disease specific health status measure, the St George's Respiratory Questionnaire (SGRQ), to predict outcomes in patients with chronic obstructive pulmonary disease (COPD). Methods: Individual patient-data of 12043 patients from long-term randomized clinical trials (2-4 years' duration) in the COPD Biomarkers Qualification Consortium database were analyzed. The adverse COPD outcomes were: exacerbations of COPD, hospital admissions due to exacerbation and all-cause mortality. Cox proportional hazards regression was used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CIs) for quartiles of SGRQ scores at baseline and time to first event, and time from first to second event, where appropriate. Results: The risk of adverse COPD outcomes increased with each increasing quartile of SGRQ score for all time to first event analyses. When comparing the lowest versus the highest quartile, the event risk (HRs [95% CIs]) increased by 40% for exacerbations (1.40 [1.29, 1.51]); 2-fold for hospital admissions (2.01 [1.78, 2.28]) and more than 2-fold for all-cause mortality (2.30 [1.91, 2.78]). For second event analyses in a subset of eligible patients, these trends persisted albeit with reduced risk estimates for exacerbations. Conclusions: Among patients with COPD, health status measured by a SGRQ score predicted exacerbations of COPD, hospital admissions due to exacerbations and their recurrence and death after adjustment. These data support the rationale for a health status measure use as a drug development tool and suggest that a health status measure may also have a role in risk assessment for COPD patients in routine medical care.

Item Type: Article
Additional Information: Provided here with permission from the COPDF Foundation. Originally published at http://doi.org/10.15326/jcopdf.4.2.2017.0131
Keywords: CBQC, COPD Biomarkers Qualification Consortium, COPD outcomes, SGRQ, St George’s Respiratory Questionnaire, predictive validity
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Chronic Obstr Pulm Dis
ISSN: 2372-952X
Language: eng
Dates:
DateEvent
28 March 2017Published
1 February 2017Accepted
Publisher License: Publisher's own licence
PubMed ID: 28848923
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109133
Publisher's version: https://doi.org/10.15326/jcopdf.4.2.2017.0131

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