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Contrast agents for cardiovascular magnetic resonance imaging: an overview

Meloni, MM; Barton, S; Xu, L; Kaski, JC; Song, W; He, T (2017) Contrast agents for cardiovascular magnetic resonance imaging: an overview. J. Mater. Chem. B, 5 (29). pp. 5714-5725. ISSN 2050-750X https://doi.org/10.1039/C7TB01241A
SGUL Authors: Meloni, Marco Massimiliano

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Abstract

Cardiovascular Magnetic Resonance (CMR), a non-invasive and nonionizing imaging technique, plays a major role in research and clinical cardiology. The strength of CMR lies in its high temporal resolution, superior contrast, and unique tissue characterization capabilities. Contrast agents have been used to improve sensitivity and specificity of CMR in detecting and evaluating various pathologies. Much effort has been made to develop more efficient contrast reagents to detect cardiovascular diseases at an asymptomatic stage, which has led to a plethora of products in animal studies. However, very few of the developed contrast agents are currently approved for human use. Major obstacles are high dosages, toxicity, body clearance rate and long-term immunogenicity. In this review, we critically assess recent developments in the field of the contrast agents for CMR, highlighting both benefits and current drawbacks. A clearer insight regarding the challenges facing the development of improved contrast agents may help collaborative work to enhance images contrast, decrease toxicity and accelerate their translation into clinical use.

Item Type: Article
Additional Information: This is the accepted version of an article published in Journal of Materials Chemistry B. The version of record is available online at http://doi.org/10.1039/C7TB01241A
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: J. Mater. Chem. B
ISSN: 2050-750X
Dates:
DateEvent
7 August 2017Published
4 July 2017Published Online
23 May 2017Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
FS/15/17/31411British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
URI: https://openaccess.sgul.ac.uk/id/eprint/109047
Publisher's version: https://doi.org/10.1039/C7TB01241A

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