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Twin-Twin Transfusion Syndrome: study protocol for developing, disseminating, and implementing a core outcome set.

Khalil, A; Perry, H; Duffy, J; Reed, K; Baschat, A; Deprest, J; Hecher, K; Lewi, L; Lopriore, E; Oepkes, D; et al. Khalil, A; Perry, H; Duffy, J; Reed, K; Baschat, A; Deprest, J; Hecher, K; Lewi, L; Lopriore, E; Oepkes, D; International Collaboration to Harmonise Outcomes for Twin–Twin (2017) Twin-Twin Transfusion Syndrome: study protocol for developing, disseminating, and implementing a core outcome set. Trials, 18 (1). p. 325. ISSN 1745-6215 https://doi.org/10.1186/s13063-017-2042-0
SGUL Authors: Khalil, Asma

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Abstract

BACKGROUND: Twin-Twin Transfusion Syndrome (TTTS) is associated with an increased risk of perinatal mortality and morbidity. Several treatment interventions have been described for TTTS, including fetoscopic laser surgery, amnioreduction, septostomy, expectant management, and pregnancy termination. Over the last decade, fetoscopic laser surgery has become the primary treatment. The literature to date reports on many different outcomes, making it difficult to compare results or combine data from individual studies, limiting the value of research to guide clinical practice. With the advent and ongoing development of new therapeutic techniques, this is more important than ever. The development and use of a core outcome set has been proposed to address these issues, prioritising outcomes important to the key stakeholders, including patients. We aim to produce, disseminate, and implement a core outcome set for TTTS. METHODS: An international steering group has been established to oversee the development of this core outcome set. This group includes healthcare professionals, researchers and patients. A systematic review is planned to identify previously reported outcomes following treatment for TTTS. Following completion, the identified outcomes will be evaluated by stakeholders using an international, multi-perspective online modified Delphi method to build consensus on core outcomes. This method encourages the participants towards consensus 'core' outcomes. All key stakeholders will be invited to participate. The steering group will then hold a consensus meeting to discuss results and form a core outcome set to be introduced and measured. Once core outcomes have been agreed, the next step will be to determine how they should be measured, disseminated, and implemented within an international context. DISCUSSION: The development, dissemination, and implementation of a core outcome set in TTTS will enable its use in future clinical trials, systematic reviews and clinical practice guidelines. This is likely to advance the quality of research studies and their effective use in order to guide clinical practice and improve patient care, maternal, short-term perinatal outcomes and long-term neurodevelopmental outcomes. TRIAL REGISTRATION: Core Outcome Measures in Effectiveness Trials (COMET), 921 Registered on July 2016. International Prospective Register of Systematic Reviews (PROSPERO), CRD42016043999 . Registered on 2 August 2016.

Item Type: Article
Additional Information: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Core outcome set, Modified Delphi method, Twin–Twin Transfusion Syndrome, General & Internal Medicine, 1102 Cardiovascular Medicine And Haematology, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Trials
ISSN: 1745-6215
Language: eng
Dates:
DateEvent
14 July 2017Published
16 June 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 28709445
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109008
Publisher's version: https://doi.org/10.1186/s13063-017-2042-0

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