Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Melanocortin receptor accessory proteins in adrenal disease and obesity.

Jackson, DS; Ramachandrappa, S; Clark, AJ; Chan, LF (2015) Melanocortin receptor accessory proteins in adrenal disease and obesity. Front Neurosci, 9. p. 213. ISSN 1662-4548
SGUL Authors: Clark, Adrian John L

PDF Published Version
Available under License Creative Commons Attribution.

Download (621kB) | Preview


Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor. The importance of MRAP in adrenal gland physiology is demonstrated by the clinical condition familial glucocorticoid deficiency type 2. The role of its paralog melanocortin-2-receptor accessory protein 2 (MRAP2), which is predominantly expressed in the hypothalamus including the paraventricular nucleus, has recently been linked to mammalian obesity. Whole body deletion and targeted brain specific deletion of the Mrap2 gene result in severe obesity in mice. Interestingly, Mrap2 complete knockout (KO) mice have increased body weight without detectable changes to food intake or energy expenditure. Rare heterozygous variants of MRAP2 have been found in humans with severe, early-onset obesity. In vitro data have shown that Mrap2 interaction with the melanocortin-4-receptor (Mc4r) affects receptor signaling. However, the mechanism by which Mrap2 regulates body weight in vivo is not fully understood and differences between the phenotypes of Mrap2 and Mc4r KO mice may point toward Mc4r independent mechanisms.

Item Type: Article
Additional Information: Copyright © 2015 Jackson, Ramachandrappa, Clark and Chan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) ( The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: accessory proteins, adrenal function, knockout mouse model, melanocortin receptors, obesity, melanocortin receptors, accessory proteins, adrenal function, obesity, knockout mouse model, 1109 Neurosciences, 1702 Cognitive Science
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Front Neurosci
ISSN: 1662-4548
Language: eng
10 June 2015Published
28 May 2015Accepted
Publisher License: Creative Commons: Attribution 4.0
Project IDFunderFunder ID
G0802796Medical Research Council
PubMed ID: 26113808
Web of Science ID: WOS:000362001100001
Go to PubMed abstract
Publisher's version:

Actions (login required)

Edit Item Edit Item