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Conventional Antibiotics – Revitalized by New Agents

Coates, ARM; Hu, Y (2014) Conventional Antibiotics – Revitalized by New Agents. In: Novel Antimicrobial Agents and Strategies. (eds Phoenix, DA; Harris, F; Dennison, SR.) Wiley-VCH, Weinheim, Germany, pp. 17-30.
SGUL Authors: Coates, Anthony Robert Milnes Hu, Yanmin

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Abstract

β-lactamase inhibitors are clinically proven to revitalize old β-lactam antibiotics by neutralizing bacterial β-lactamases. We call these compounds antibiotic resistance breakers (ARB). Unfortunately, bacteria express more than 1000 β-lactamases, of which the metallo-beta-lactamases are proving difficult to neutralize. Here, we describe other antibiotic resistant breakers, which are not yet in the clinic, but which potentially revitalize other classes of antibiotics. These include aminoglycoside-modifying enzyme inhibitors, efflux pump inhibitors, and compounds that are associated with increased permeability of the bacterial cell membrane. If it were possible to develop new ARB for many different classes of antibiotics, this approach could be a viable alternative to the more expensive single novel compound route that has been pursued for pyogenic bacterial infections.

Item Type: Book Section
Additional Information: Copyright 2014 Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission. This permission does not include the right to grant others permission to photocopy or otherwise reproduce this material except for accessible versions made by non-profit organizations serving the blind, visually impaired and other persons with print disabilities (VIPs).
Keywords: Medical
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Editors: Phoenix, DA; Harris, F; Dennison, SR
ISBN: 3527336389, 9783527336388
Dates:
DateEvent
24 November 2014Published
14 November 2014Published Online
Publisher License: Publisher's own licence
URI: https://openaccess.sgul.ac.uk/id/eprint/108638

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