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Maternal immunisation: collaborating with mother nature.

Marchant, A; Sadarangani, M; Garand, M; Dauby, N; Verhasselt, V; Pereira, L; Bjornson, G; Jones, CE; Halperin, SA; Edwards, KM; et al. Marchant, A; Sadarangani, M; Garand, M; Dauby, N; Verhasselt, V; Pereira, L; Bjornson, G; Jones, CE; Halperin, SA; Edwards, KM; Heath, P; Openshaw, PJ; Scheifele, DW; Kollmann, TR (2017) Maternal immunisation: collaborating with mother nature. Lancet Infect Dis, 17 (7). e197-e208. ISSN 1474-4457 https://doi.org/10.1016/S1473-3099(17)30229-3
SGUL Authors: Heath, Paul Trafford Jones, Christine Elizabeth

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Abstract

Maternal immunisation has the potential to substantially reduce morbidity and mortality from infectious diseases after birth. The success of tetanus, influenza, and pertussis immunisation during pregnancy has led to consideration of additional maternal immunisation strategies to prevent group B streptococcus and respiratory syncytial virus infections, among others. However, many gaps in knowledge regarding the immunobiology of maternal immunisation prevent the optimal design and application of this successful public health intervention. Therefore, we did an innovative landscape analysis to identify research priorities. Key topics were delineated through review of the published literature, consultation with vaccine developers and regulatory agencies, and a collaborative workshop that gathered experts across several maternal immunisation initiatives-group B streptococcus, respiratory syncytial virus, pertussis, and influenza. Finally, a global online survey prioritised the identified knowledge gaps on the basis of expert opinion about their importance and relevance. Here we present the results of this worldwide landscape analysis and discuss the identified research gaps.

Item Type: Article
Additional Information: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Microbiology, 1103 Clinical Sciences, 1108 Medical Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Lancet Infect Dis
ISSN: 1474-4457
Language: eng
Dates:
DateEvent
July 2017Published
19 April 2017Published Online
7 February 2017Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 28433705
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/108595
Publisher's version: https://doi.org/10.1016/S1473-3099(17)30229-3

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