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Bringing memory fMRI to the clinic: comparison of seven memory fMRI protocols in temporal lobe epilepsy.

Towgood, K; Barker, GJ; Caceres, A; Crum, WR; Elwes, RDC; Costafreda, SG; Mehta, MA; Morris, RG; von Oertzen, TJ; Richardson, MP (2015) Bringing memory fMRI to the clinic: comparison of seven memory fMRI protocols in temporal lobe epilepsy. Hum Brain Mapp, 36 (4). pp. 1595-1608. ISSN 1097-0193
SGUL Authors: Von Oertzen, Tim

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fMRI is increasingly implemented in the clinic to assess memory function. There are multiple approaches to memory fMRI, but limited data on advantages and reliability of different methods. Here, we compared effect size, activation lateralisation, and between-sessions reliability of seven memory fMRI protocols: Hometown Walking (block design), Scene encoding (block design and event-related design), Picture encoding (block and event-related), and Word encoding (block and event-related). All protocols were performed on three occasions in 16 patients with temporal lobe epilepsy (TLE). Group T-maps showed activity bilaterally in medial temporal lobe for all protocols. Using ANOVA, there was an interaction between hemisphere and seizure-onset lateralisation (P = 0.009) and between hemisphere, protocol and seizure-onset lateralisation (P = 0.002), showing that the distribution of memory-related activity between left and right temporal lobes differed between protocols and between patients with left-onset and right-onset seizures. Using voxelwise intraclass Correlation Coefficient, between-sessions reliability was best for Hometown and Scenes (block and event). The between-sessions spatial overlap of activated voxels was also greatest for Hometown and Scenes. Lateralisation of activity between hemispheres was most reliable for Scenes (block and event) and Words (event). Using receiver operating characteristic analysis to explore the ability of each fMRI protocol to classify patients as left-onset or right-onset TLE, only the Words (event) protocol achieved a significantly above-chance classification of patients at all three sessions. We conclude that Words (event) protocol shows the best combination of between-sessions reliability of the distribution of activity between hemispheres and reliable ability to distinguish between left-onset and right-onset patients.

Item Type: Article
Additional Information: © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: fMRI, reliability, reproducibility, temporal lobe epilepsy, Adult, Brain, Brain Mapping, Clinical Protocols, Epilepsy, Temporal Lobe, Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuropsychological Tests, ROC Curve, Reproducibility of Results, Signal Processing, Computer-Assisted, Young Adult, Brain, Humans, Epilepsy, Temporal Lobe, Magnetic Resonance Imaging, Clinical Protocols, Brain Mapping, Reproducibility of Results, ROC Curve, Memory, Neuropsychological Tests, Signal Processing, Computer-Assisted, Adult, Middle Aged, Female, Male, Functional Laterality, Young Adult, Experimental Psychology, 1109 Neurosciences, 1702 Cognitive Science
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Hum Brain Mapp
ISSN: 1097-0193
Language: eng
April 2015Published
2 March 2015Published Online
11 December 2014Accepted
Publisher License: Creative Commons: Attribution 4.0
Project IDFunderFunder ID
MR/K013998/1Medical Research CouncilUNSPECIFIED
WT 088641/Z/09/ZWellcome TrustUNSPECIFIED
PubMed ID: 25727386
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