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Hypoxia and Pulmonary Hypertension

Charolidi, N; Carroll, VA (2017) Hypoxia and Pulmonary Hypertension. In: Hypoxia and Human Diseases. (eds Zheng, J; Zhou, C.) INTECH. DOI: https://doi.org/10.5772/67151
SGUL Authors: Carroll, Veronica Charolidi, Nicoletta

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Abstract

Vasoconstriction in response to low oxygen tension (hypoxia) in pulmonary arteries is an important physiological adaptation to reroute blood flow to areas of higher oxygenation for effective gaseous exchange. However, chronic hypoxia is a common feature of lung disease, such as chronic obstructive pulmonary disease (COPD). Hypoxic stress triggers cellular phenotypic alterations including increased proliferation and migration of vascular smooth muscle cells (VSMCs), as well as synthesis of extracellular matrix (ECM) proteins that remodel lung vasculature. Remodelling of vessels increases the risk of pulmonary hypertension (PH)—elevated pulmonary arterial pressure—and eventually right heart failure. This chapter will summarise the major pathways and mechanisms involved in hypoxia-driven pulmonary hypertension (PH).

Item Type: Book Section
Additional Information: © 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Editors: Zheng, J; Zhou, C
ISBN: 978-953-51-2896-0
Dates:
DateEvent
1 February 2017Published
Publisher License: Creative Commons: Attribution 3.0
URI: https://openaccess.sgul.ac.uk/id/eprint/108491
Publisher's version: https://doi.org/10.5772/67151

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