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Short-term associations between particle oxidative potential and daily mortality and hospital admissions in London.

Atkinson, RW; Samoli, E; Analitis, A; Fuller, GW; Green, DC; Anderson, HR; Purdie, E; Dunster, C; Aitlhadj, L; Kelly, FJ; et al. Atkinson, RW; Samoli, E; Analitis, A; Fuller, GW; Green, DC; Anderson, HR; Purdie, E; Dunster, C; Aitlhadj, L; Kelly, FJ; Mudway, IS (2016) Short-term associations between particle oxidative potential and daily mortality and hospital admissions in London. International Journal of Hygiene and Environmental Health, 219 (6). pp. 566-572. https://doi.org/10.1016/j.ijheh.2016.06.004
SGUL Authors: Anderson, Hugh Ross Atkinson, Richard William

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Abstract

BACKGROUND: Particulate matter (PM) from traffic and other sources has been associated with adverse health effects. One unifying theory is that PM, whatever its source, acts on the human body via its capacity to cause damaging oxidation reactions related to its content of pro-oxidants components. Few epidemiological studies have investigated particle oxidative potential (OP) and health. We conducted a time series analysis to assess associations between daily particle OP measures and numbers of deaths and hospital admissions for cardiovascular and respiratory diseases. METHODS: During 2011 and 2012 particles with an aerodynamic diameter less than 2.5 and 10μm (PM2.5 and PM10 respectively) were collected daily on Partisol filters located at an urban background monitoring station in Central London. Particulate OP was assessed based on the capacity of the particles to oxidize ascorbate (OP(AA)) and glutathione (OP(GSH)) from a simple chemical model reflecting the antioxidant composition of human respiratory tract lining fluid. Particulate OP, expressed as % loss of antioxidant per μg of PM, was then multiplied by the daily concentrations of PM to derive the daily OP of PM mass concentrations (% loss per m(3)). Daily numbers of deaths and age- and cause-specific hospital admissions in London were obtained from national registries. Poisson regression accounting for seasonality and meteorology was used to estimate the percentage change in risk of death or admission associated with an interquartile increment in particle OP. RESULTS: We found little evidence for adverse associations between OP(AA) and OP(GSH) and mortality. Associations with cardiovascular admissions were generally positive in younger adults and negative in older adults with confidence intervals including 0%. For respiratory admissions there was a trend, from positive to negative associations, with increasing age although confidence intervals generally included 0%. CONCLUSIONS: Our study, the first to analyse daily particle OP measures and mortality and admissions in a large population over two years, found little evidence to support the hypothesis that short-term exposure to particle OP is associated with adverse health effects. Further studies with improved exposure assessment and longer time series are required to confirm or reject the role of particle OP in triggering exacerbations of disease.

Item Type: Article
Additional Information: © 2016 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Environmental epidemiology, Hospital admissions, Mortality, Oxidative potential, Particles, Time series, Oxidative potential, Particles, Mortality, Hospital admissions, Time series, Environmental epidemiology, Toxicology, 1117 Public Health And Health Services
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: International Journal of Hygiene and Environmental Health
Language: ENG
Dates:
DateEvent
5 June 2016Published Online
3 June 2016Accepted
1 August 2016Published
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
NE/10078571Natural Environment Research Councilhttp://dx.doi.org/10.13039/501100000270
PubMed ID: 27350257
Web of Science ID: WOS:000381590400010
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107946
Publisher's version: https://doi.org/10.1016/j.ijheh.2016.06.004

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