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Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Strachan, D; Gormley, P; Anttila, V; Winsvold, BS; Palta, P; Esko, T; Pers, TH; Farh, KH; Cuenca-Leon, E; Muona, M; et al. Strachan, D; Gormley, P; Anttila, V; Winsvold, BS; Palta, P; Esko, T; Pers, TH; Farh, KH; Cuenca-Leon, E; Muona, M; Furlotte, NA; Kurth, T; Ingason, A; McMahon, G; Ligthart, L; Terwindt, GM; Kallela, M; Freilinger, TM; Ran, C; Gordon, SG; Stam, AH; Steinberg, S; Borck, G; Koiranen, M; Quaye, L; Adams, HHH; Lehtimäki, T; Sarin, AP; Wedenoja, J; Hinds, DA; Buring, JE; Schürks, M; Ridker, PM; Hrafnsdottir, MG; Stefansson, H; Ring, SM; Hottenga, JJ; Penninx, BW; Färkkilä, M; Artto, V; Kaunisto, M; Vepsalainen, S; Malik, R; Heath, AC; Madden, PA; Martin, NG; Montgomery, GW; Kurki, M; Kals, M; Mägi, R; Parn, K; Hamalainen, E; Huang, H; Byrnes, AE; Franke, L; Huang, J; Stergiakouli, E; Lee, PH; Sandor, C; Webber, C; Cader, Z; Muller-Myhsok, B; Schreiber, S; Meitinger, T; Eriksson, JG; Salomaa, V; Heikkilä, K; Loehrer, E; Uitterlinden, AG; Hofman, A; van Duijn, CM; Cherkas, L; Pedersen, LM; Stubhaug, A; Nielsen, CS; Mannikko, M; Mihailov, E; Milani, L; Göbel, H; Esserlind, AL; Christensen, AF; Folkmann Hansen, T; Werge, T; International Headache Genetics Consortium, IHGC; Kaprio, J; Aromaa, A; Raitakari, O; Arfan Ikram, M; Spector, T; Jarvelin, MR; Metspalu, A; Kubisch, C; Ferrari, MD; Belin, AC; Dichgans, M; Wessman, M; van den Maagdenberg, AM; Zwart, JA; Boomsma, DI; Smith, GD; Stefansson, K; Eriksson, N; Daly, MJ; Neale, BM; Olesen, J; Chasman, DI; Nyholt, DR; Palotie, A (2016) Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48. pp. 856-866. ISSN 1546-1718 https://doi.org/10.1038/ng.3598
SGUL Authors: Strachan, David Peter

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Abstract

Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10−8) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to our knowledge is the first to be identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.

Item Type: Article
Additional Information: © Nature America Inc, All Rights Reserved. The published article can be accessed here: http://dx.doi.org/10.1038/ng.3598
Keywords: Developmental Biology, 11 Medical And Health Sciences, 06 Biological Sciences
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Nature Genetics
ISSN: 1546-1718
Dates:
DateEvent
20 June 2016Published Online
10 May 2016Accepted
1 August 2016Published
Publisher License: Publisher's own licence
URI: https://openaccess.sgul.ac.uk/id/eprint/107923
Publisher's version: https://doi.org/10.1038/ng.3598

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