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Dopamine restores reward prediction errors in old age.

Chowdhury, R; Guitart-Masip, M; Lambert, C; Dayan, P; Huys, Q; Düzel, E; Dolan, RJ (2013) Dopamine restores reward prediction errors in old age. Nature Neuroscience, 16 (5). pp. 648-653. ISSN 1546-1726 https://doi.org/10.1038/nn.3364
SGUL Authors: Lambert, Christian Paul

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Abstract

Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value, resulting in an incomplete reward prediction error (RPE) signal in the nucleus accumbens, a brain region that receives rich input projections from substantia nigra/ventral tegmental area (SN/VTA) dopaminergic neurons. Structural connectivity between SN/VTA and striatum, measured by diffusion tensor imaging, was tightly coupled to inter-individual differences in the expression of this expected reward value signal. The dopamine precursor levodopa (L-DOPA) increased the task-based learning rate and task performance in some older adults to the level of young adults. This drug effect was linked to restoration of a canonical neural RPE. Our results identify a neurochemical signature underlying abnormal reward processing in older adults and indicate that this can be modulated by L-DOPA.

Item Type: Article
Additional Information: Author’s manuscript is made available for academic research only, and cannot be used for commercial purposes without prior permission of the copyright holders. Made available here with permission from the publisher.
Keywords: Adult, Aged, Aging, Alkaloids, Brain, Conditioning, Operant, Dopamine Agents, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Levodopa, Magnetic Resonance Imaging, Male, Oxygen, Reinforcement (Psychology), Reward, Time Factors, Young Adult, Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, NEUROSCIENCES, REINFORCEMENT LEARNING SIGNALS, NUCLEUS-ACCUMBENS DOPAMINE, FINANCIAL RISK-TAKING, DECISION-MAKING, PARKINSONS-DISEASE, HUMAN STRIATUM, DIFFUSION MRI, SPIN-ECHO, HUMANS, BRAIN, Neurology & Neurosurgery, 1109 Neurosciences, 1702 Cognitive Science
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Neuroscience (INCCNS)
Journal or Publication Title: Nature Neuroscience
ISSN: 1546-1726
Language: eng
Dates:
DateEvent
May 2013Published
PubMed ID: 23525044
Web of Science ID: WOS:000318029300022
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107308
Publisher's version: https://doi.org/10.1038/nn.3364

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