Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque.

Chan, CF; Keenan, NG; Nielles-Vallespin, S; Gatehouse, P; Sheppard, MN; Boyle, JJ; Pennell, DJ; Firmin, DN (2010) Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque. Journal of Cardiovascular Magnetic Resonance, 12 (17). ISSN 1532-429X
SGUL Authors: Sheppard, Mary Noelle

["document_typename_application/pdf; charset=binary" not defined] Published Version
Download (1MB) | Preview


BACKGROUND: Multi-contrast weighted cardiovascular magnetic resonance (CMR) allows detailed plaque characterisation and assessment of plaque vulnerability. The aim of this preliminary study was to show the potential of Ultra-short Echo Time (UTE) subtraction MR in detecting calcification. METHODS: 14 ex-vivo human carotid arteries were scanned using CMR and CT, prior to histological slide preparation. Two images were acquired using a double-echo 3D UTE pulse, one with a long TE and the second with an ultra-short TE, with the same TR. An UTE subtraction (DeltaUTE) image containing only ultra-short T2 (and T2*) signals was obtained by post-processing subtraction of the 2 UTE images. The DeltaUTE image was compared to the conventional 3D T1-weighted sequence and CT scan of the carotid arteries. RESULTS: In atheromatous carotid arteries, there was a 71% agreement between the high signal intensity areas on DeltaUTE images and CT scan. The same areas were represented as low signal intensity on T1W and areas of void on histology, indicating focal calcification. However, in 15% of all the scans there were some incongruent regions of high intensity on DeltaUTE that did not correspond with a high intensity signal on CT, and histology confirmed the absence of calcification. CONCLUSIONS: We have demonstrated that the UTE sequence has potential to identify calcified plaque. Further work is needed to fully understand the UTE findings.

Item Type: Article
Additional Information: © 2010 Chan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Adult, Aged, Aged, 80 and over, Calcinosis, Carotid Artery Diseases, Carotid Artery, Common, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Pilot Projects, Predictive Value of Tests, Time Factors, Tomography, X-Ray Computed, Young Adult, Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Radiology, Nuclear Medicine & Medical Imaging, Cardiovascular System & Cardiology, CARDIAC & CARDIOVASCULAR SYSTEMS, RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING, CORONARY-ARTERY DISEASE, UTE PULSE SEQUENCES, IN-VIVO, MYOCARDIAL-INFARCTION, MRI, CALCIUM, RISK, CLASSIFICATION, CALCIFICATION, ANGIOGRAPHY, Nuclear Medicine & Medical Imaging, 1102 Cardiovascular Medicine And Haematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: Journal of Cardiovascular Magnetic Resonance
ISSN: 1532-429X
Language: eng
PubMed ID: 20346110
Web of Science ID: WOS:000276646700001
Go to PubMed abstract
Publisher's version:

Actions (login required)

Edit Item Edit Item