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Risk factors for atopic and non-atopic asthma in a rural area of Ecuador

Moncayo, AL; Vaca, M; Oviedo, G; Erazo, S; Quinzo, I; Fiaccone, RL; Chico, ME; Barreto, ML; Cooper, PJ (2010) Risk factors for atopic and non-atopic asthma in a rural area of Ecuador. THORAX, 65 (5). 409 - 416. ISSN 0040-6376
SGUL Authors: Cooper, Philip John

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Background: Asthma has emerged as an important public health problem of urban populations in Latin America. Epidemiological data suggest that a minority of asthma cases in Latin America may be associated with allergic sensitisation and that other mechanisms causing asthma have been overlooked. The aim of the present study was to investigate risk factors for atopic and non-atopic asthma in school-age children. Methods: A cross-sectional study was conducted among 3960 children aged 6–16 years living in Afro-Ecuadorian rural communities in Esmeraldas province in Ecuador. Allergic diseases and risk factors were assessed by questionnaire and allergic sensitisation by allergen skin prick reactivity. Results: A total of 390 (10.5%) children had wheeze within the previous 12 months, of whom 14.4% had at least one positive skin test. The population-attributable fraction for recent wheeze associated with atopy was 2.4%. Heavy Trichuris trichiura infections were strongly inversely associated with atopic wheeze. Non-atopic wheeze was positively associated with maternal allergic symptoms and sedentarism (watching television (>3 h/day)) but inversely associated with age and birth order. Conclusions: The present study showed a predominance of non-atopic compared with atopic wheeze among schoolchildren living in a poor rural region of tropical Latin America. Distinct risk factors were associated with the two wheeze phenotypes and may indicate different causal mechanisms. Future preventive strategies in such populations may need to be targeted at the causes of non-atopic wheeze.

Item Type: Article
Additional Information: This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license
Keywords: Adolescent, Allergens, Asthma, Child, Cross-Sectional Studies, Ecuador, Female, Humans, Hypersensitivity, Immediate, Male, Respiratory Sounds, Risk Factors, Rural Health, Skin Tests, Socioeconomic Factors, Science & Technology, Life Sciences & Biomedicine, Respiratory System, RESPIRATORY SYSTEM, PHYSICAL-ACTIVITY, RESPIRATORY SYMPTOMS, DIFFERENT PATTERN, CHILDREN, SENSITIZATION, CHILDHOOD, SCHOOLCHILDREN, PREVALENCE, INFECTIONS, PROTECT, Respiratory System, 1103 Clinical Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: THORAX
ISSN: 0040-6376
Related URLs:
1 May 2010Published
Web of Science ID: WOS:000277193900009
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