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A salty cause of severe hypertension.

Ruiz-Granados, ES; Shouls, G; Sainsbury, C; Antonios, T (2012) A salty cause of severe hypertension. BMJ Case Rep, 2012. pp. 1-2. https://doi.org/10.1136/bcr.12.2011.5336
SGUL Authors: Antonios, Tarek Francis Tewfik

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Abstract

A 51-year-old lady was referred to our clinic because of severe hypertension; blood pressure 214/119 mm Hg despite treatment with an angiotensin receptor antagonist and a calcium channel blocker. Her initial laboratory results showed hypokalaemic alkalosis with normal urea and creatinine levels. Her 24-h urinary sodium excretion was markedly elevated at 244 mmol (equivalent to a daily intake of approximately 16 g of salt). Hyperaldosteronism was suspected but her plasma aldosterone level was subsequently found to be normal. On further questioning, the patient admitted to eating considerable amounts of salted liquorice and a diagnosis of acquired apparent mineralocorticoid excess was made. Liquorice has a well-known mineralocorticoid activity as it inhibits the action of 11β-hydroxysteroid dehydrogenase 2 and can induce mineralocorticoid hypertension. After stopping eating the salted liquorice, the patient's blood pressure quickly normalised and all her antihypertensive medications were stopped.

Item Type: Article
Additional Information: PMCID: PMC3291023
Keywords: Acute Disease, Female, Glycyrrhiza, Humans, Hypertension, Middle Aged, Sodium, Dietary
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: BMJ Case Rep
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Dates:
DateEvent
28 February 2012Published
PubMed ID: 22665565
Web of Science ID: 22665565
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URI: https://openaccess.sgul.ac.uk/id/eprint/105083
Publisher's version: https://doi.org/10.1136/bcr.12.2011.5336

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