SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Do ethnic differences in cord blood leptin levels differ by birthweight category? Findings from the Born in Bradford cohort study.

West, J; Wright, J; Fairley, L; Sattar, N; Whincup, P; Lawlor, DA (2014) Do ethnic differences in cord blood leptin levels differ by birthweight category? Findings from the Born in Bradford cohort study. International Journal of Epidemiology, 43 (1). pp. 249-254. ISSN 1464-3685 https://doi.org/10.1093/ije/dyt225
SGUL Authors: Whincup, Peter Hynes

[img]
Preview
["document_typename_application/pdf; charset=binary" not defined] Published Version
Download (130kB) | Preview

Abstract

BACKGROUND: There is evidence that South Asian individuals have higher fat mass for a given weight than Europeans. One study reported that the greater fatness for a given birthweight may increase with increasing birth weight, suggesting that any attempt to increase mean birth weight in South Asians would markedly increase their fatness. OBJECTIVE: Our objective was to examine whether differences in cord leptin values between White British and Pakistani infants vary by birth weight category. METHOD: We examined the difference in cord leptin levels between 659 White British and 823 Pakistani infants recruited to the Born in Bradford cohort study, by clinical categories and thirds of the birth weight distribution. RESULTS: Pakistani infants had a lower mean birthweight but higher cord leptin levels than White British infants [ratio of geometric mean(RGM) of cord leptin adjusted for birth weight = 1.36 (95% CI 1.26,1.46)]. Birthweight was positively associated with cord leptin levels in both groups, with no evidence that the regression lines in the two groups diverged from each other with increasing birthweight.The relative ethnic difference in cord leptin was similar in low (<2500 g), normal and high (≥4000 g) birthweight infants(P-value for interaction = 0.91). It was also similar across thirds of the birthweight distribution [RGM (95% CI) in lowest, mid and highest thirds were 1.37 (1.20, 1.57), 1.36 (1.20, 1.54) and 1.31 (1.16, 1.52), respectively, P-interaction = 0.51]. CONCLUSIONS: We found marked differences in cord leptin levels between Pakistani and White British infants but no evidence that this difference increases with increasing birthweight.

Item Type: Article
Additional Information: Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Article originally made available by Publisher via Advance Access publication 30 November 2013.
Keywords: Epidemiology, 0104 Statistics, 1117 Public Health And Health Services
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: International Journal of Epidemiology
ISSN: 1464-3685
Language: eng
Dates:
DateEvent
February 2014Published
PubMed ID: 24291804
Web of Science ID: 24291804
Download EPMC Full text (PDF)
Download EPMC Full text (HTML)
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/105077
Publisher's version: https://doi.org/10.1093/ije/dyt225

Actions (login required)

Edit Item Edit Item