SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Predicting aortic complications after endovascular aneurysm repair

Karthikesalingam, A; Holt, PJ; Vidal-Diez, A; Choke, EC; Patterson, BO; Thompson, LJ; Ghatwary, T; Bown, MJ; Sayers, RD; Thompson, MM (2013) Predicting aortic complications after endovascular aneurysm repair. BRITISH JOURNAL OF SURGERY, 100 (10). 1302 - 1311 (10). ISSN 0007-1323 https://doi.org/10.1002/bjs.9177
SGUL Authors: Holt, Peter James Edward Thompson, Matthew Merfyn Vidal-Diez, Alberto

Full text not available from this repository.

Abstract

Background Lifelong surveillance is standard after endovascular repair of abdominal aortic aneurysm (EVAR), but remains costly, heterogeneous and poorly calibrated. This study aimed to develop and validate a scoring system for aortic complications after EVAR, informing rationalized surveillance. Methods Patients undergoing EVAR at two centres were studied from 2004 to 2010. Preoperative morphology was quantified using three-dimensional computed tomography according to a validated protocol, by investigators blinded to outcomes. Proportional hazards modelling was used to identify factors predicting aortic complications at the first centre, and thereby derive a risk score. Sidak tests between risk quartiles dichotomized patients to low- or high-risk groups. Aortic complications were reported by Kaplan–Meier analysis and risk groups were compared by log rank test. External validation was by comparison of aortic complications between risk groups at the second centre. Results Some 761 patients, with a median age of 75 (interquartile range 70–80) years, underwent EVAR. Median follow-up was 36 (range 11–94) months. Physiological variables were not associated with aortic complications. A morphological risk score incorporating maximum aneurysm diameter (P < 0·001) and largest common iliac diameter (measured 10 mm from the internal iliac origin; P = 0·004) allocated 75 per cent of patients to a low-risk group, with excellent discrimination between 5-year rates of aortic complication in low- and high-risk groups at both centres (centre 1: 12 versus 31 per cent, P < 0·001; centre 2: 12 versus 45 per cent, P = 0·002). Conclusion The risk score uses commonly available morphological data to stratify the rate of complications after EVAR. The proposals for rationalized surveillance could provide clinical and economic benefits.

Item Type: Article
Additional Information: PubMed ID: 23797788
Keywords: Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal, Endoleak, Endovascular Procedures, Humans, Iliac Aneurysm, Imaging, Three-Dimensional, Kaplan-Meier Estimate, Long-Term Care, Postoperative Complications, Prospective Studies, Reoperation, Risk Assessment, Tomography, X-Ray Computed, Torsion Abnormality, Science & Technology, Life Sciences & Biomedicine, Surgery, SURGERY, NECK ANATOMY, COMPUTED-TOMOGRAPHY, REPORTING STANDARDS, EVAR, SURVEILLANCE, MORPHOLOGY, DIAMETER, OUTCOMES, MODEL, RISK
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Vascular & Cardiac Surgery (INCCVC)
Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: BRITISH JOURNAL OF SURGERY
ISSN: 0007-1323
Related URLs:
Dates:
DateEvent
1 September 2013Published
Web of Science ID: WOS:000322960000008
URI: https://openaccess.sgul.ac.uk/id/eprint/104529
Publisher's version: https://doi.org/10.1002/bjs.9177

Actions (login required)

Edit Item Edit Item