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Cancer genetics services in Europe

Hodgson, S; Milner, B; Brown, I; Bevilacqua, G; Chang-Claude, J; Eccles, D; Evans, G; Gregory, H; Møller, P; Morrison, P; et al. Hodgson, S; Milner, B; Brown, I; Bevilacqua, G; Chang-Claude, J; Eccles, D; Evans, G; Gregory, H; Møller, P; Morrison, P; Steel, M; Stoppa-Lyonnet, D; Vasen, H; Haites, N (1999) Cancer genetics services in Europe. DISEASE MARKERS, 15 (1-3). 3 - 13 (11). ISSN 0278-0240 https://doi.org/10.1155/1999/134945
SGUL Authors: Hodgson, Shirley Victoria

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Abstract

It has long been recognised that some very rare forms of cancer predisposition, such as retinoblastoma, are caused by inherited gene mutations [7]. It is only within the last decade or so, however, that rapid progress has been made in understanding the role that inherited mutations also play in determining a proportion of the more common cancers, including breast, colorectal and ovarian cancer [1,2,3,4,6,8,9,10]. Although there is still uncertainty about the precise contribution of inherited predisposition genes to the incidence of these cancers, the available evidence suggests that breast, colorectal and ovarian cancer have a number of common genetic features: • A small proportion of these cancers (about 5%) are caused by inherited gene mutations which, though comparatively rare, confer very high lifetime risks of developing cancer. In some cases these lifetime risks may be as high as 80%. • Cancers caused by these high-penetrance genes are likely to occur at an earlier age than sporadic cancers, and 15 – 20% of the cancers diagnosed in people under the age of 50 may be accounted for by these genetic mutations. • Carriers of known genetic mutations which confer high lifetime risks of developing breast, colorectal or ovarian cancer are also at a somewhat increased risk of developing certain other forms of cancer. • A further 10 – 20% of breast, colorectal and ovarian cancers may be caused by other inherited predisposition genes which are less penetrant but which confer some increased risk (more than 3 times the general population risk). These “medium risk”genes are only beginning to be identified.

Item Type: Article
Additional Information: PubMed ID: 10595245 Full abstract added LM 11/04/14.
Keywords: Adult, Aged, Cancer Care Facilities, Europe, Female, Genetic Counseling, Genetic Predisposition to Disease, Genetic Testing, Genetics, Medical, Great Britain, Humans, Male, Mass Screening, Middle Aged, Neoplasms, Neoplastic Syndromes, Hereditary, Oncogenes, Risk, Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Genetics & Heredity, Medicine, Research & Experimental, Pathology, Research & Experimental Medicine, BIOTECHNOLOGY & APPLIED MICROBIOLOGY, GENETICS & HEREDITY, MEDICINE, RESEARCH & EXPERIMENTAL, PATHOLOGY, COLORECTAL-CANCER, FAMILIAL BREAST, OVARIAN-CANCER, IDENTIFICATION, LINKAGE
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS)
Journal or Publication Title: DISEASE MARKERS
ISSN: 0278-0240
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Dates:
DateEvent
1 October 1999Published
Web of Science ID: WOS:000083988300002
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URI: https://openaccess.sgul.ac.uk/id/eprint/104347
Publisher's version: https://doi.org/10.1155/1999/134945

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