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Glyco-biomarkers: Potential determinants of cellular physiology and pathology

Alavi, A; Axford, JS (2008) Glyco-biomarkers: Potential determinants of cellular physiology and pathology. DISEASE MARKERS, 25 (4-5). 193 - 205 (13). ISSN 0278-0240
SGUL Authors: Axford, John Stewart

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Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly, and with it the far reaching clinical implications are becoming understood. Recent advances in high-throughput glycomic techniques, glyco biomarker profiling, glyco-bioinformatics and development of increasingly sophisticated glyco-arrays, combined with our increased understanding of the molecular details of glycosylation have facilitated the linkage between aberrant glycosylation and human diseases, and highlighted the possibility of using glyco-biomarkers as potential determinants of disease and its progression. The focus of this review is to give an insight into the biological significance of these glycomodifications, highlight some specific examples of glyco-biomarkers in relation to autoimmunity and in particular rheumatoid arthritis, and to explore the exciting possibility of exploiting these for diagnostic and prognostic strategies.

Item Type: Article
Additional Information: PubMed ID: 19126964
Keywords: Animals, Antigens, Arthritis, Rheumatoid, Autoimmunity, Biological Markers, Disease Progression, Epitopes, Glycomics, Glycosylation, Humans, Immunoglobulin G, Saccharomyces cerevisiae, Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Genetics & Heredity, Medicine, Research & Experimental, Pathology, Research & Experimental Medicine, BIOTECHNOLOGY & APPLIED MICROBIOLOGY, GENETICS & HEREDITY, MEDICINE, RESEARCH & EXPERIMENTAL, PATHOLOGY, Glycosylation, glycomics, glyco biomarkers, autoimmunity, sugar printing, glyco-antigens, immunoglobulin G, rheumatoid arthritis, BLOOD-GROUP ANTIGENS, ANTIAGALACTOSYL IGG ANTIBODIES, INFLAMMATORY-BOWEL-DISEASE, RHEUMATOID-ARTHRITIS, IMMUNOGLOBULIN-G, PROTEIN GLYCOSYLATION, N-GLYCANS, ALTERED GLYCOSYLATION, ENDOPLASMIC-RETICULUM, CONGENITAL DISORDERS, Glycosylation, glycomics, glyco biomarkers, autoimmunity, sugar printing, glyco-antigens, immunoglobulin G, rheumatoid arthritis
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: DISEASE MARKERS
ISSN: 0278-0240
Related URLs:
1 January 2008Published
Web of Science ID: WOS:000263028900002
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