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Paucity of natural killer and cytotoxic T cells in human neuromyelitis optica lesions

Saadoun, S; Bridges, LR; Verkman, AS; Papadopoulos, MC (2012) Paucity of natural killer and cytotoxic T cells in human neuromyelitis optica lesions. NEUROREPORT, 23 (18). 1044 - 1047 (4). ISSN 0959-4965 https://doi.org/10.1097/WNR.0b013e32835ab480
SGUL Authors: Papadopoulos, Marios Saadoun, Samira

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Abstract

Neuromyelitis optica is a severe inflammatory demyelinating disease of the central nervous system. Most patients with neuromyelitis optica have circulating immunoglobulin G (IgG) antibodies against the astrocytic water channel protein aquaporin-4 (AQP4), which are pathogenic. Anti-AQP4 IgG-mediated complement-dependent astrocyte toxicity is a key mechanism of central nervous system damage in neuromyelitis optica, but the role of natural killer and cytotoxic T cells is unknown. Our objective was to determine whether natural killer and cytotoxic T cells play a role in human neuromyelitis optica lesions. We immunostained four actively demyelinating lesions, obtained from patients with anti-AQP4 IgG positive neuromyelitis optica, for Granzyme B and Perforin. The inflammatory cells were perivascular neutrophils, eosinophils and macrophages, with only occasional Granzyme B+ or Perforin + cells. Greater than 95% of inflamed vessels in each lesion had no surrounding Granzyme B+ or Perforin + cells. Granzyme B+ or Perforin+ cells were abundant in human spleen (positive control). Although natural killer cells produce central nervous system damage in mice injected with anti-AQP4 IgG, our findings here indicate that natural killer-mediated and T cell-mediated cytotoxicity are probably not involved in central nervous system damage in human neuromyelitis optica.

Item Type: Article
Additional Information: PubMed ID: 23108041
Keywords: Brain, Humans, Killer Cells, Natural, Neuromyelitis Optica, T-Lymphocytes, Cytotoxic, Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, NEUROSCIENCES, antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, Devic's disease, mouse model, NMO-IgG, MULTIPLE-SCLEROSIS, INTRACEREBRAL INJECTION, IMMUNOGLOBULIN-G, IGG, COMPLEMENT, BRAIN, MICE, antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, Devic's disease, mouse model, NMO-IgG
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Neuroscience (INCCNS)
Journal or Publication Title: NEUROREPORT
ISSN: 0959-4965
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Dates:
DateEvent
19 December 2012Published
Web of Science ID: WOS:000311107800003
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URI: https://openaccess.sgul.ac.uk/id/eprint/103884
Publisher's version: https://doi.org/10.1097/WNR.0b013e32835ab480

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