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Long-term follow-up of patients treated with radiotherapy alone for early-stage histologically aggressive non-Hodgkin's lymphoma

Spicer, J; Smith, P; Maclennan, K; Hoskin, P; Hancock, B; Linch, D; Pettengell, R (2004) Long-term follow-up of patients treated with radiotherapy alone for early-stage histologically aggressive non-Hodgkin's lymphoma. BRITISH JOURNAL OF CANCER, 90 (6). 1151 - 1155 (5). ISSN 0007-0920 https://doi.org/10.1038/sj.bjc.6601675
SGUL Authors: Pettengell, Ruth

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Abstract

Historically localised aggressive non-Hodgkin's lymphoma (NHL) has been treated with involved field radiotherapy (RT), chemotherapy, or a combination of both modalities. The current weight of evidence supports a preference for combined modality treatment (CMT). Increased patient age at diagnosis is well recognised as a poor prognostic indicator in NHL, but despite this some perceive CMT as too toxic for use in the elderly. As a result, some older patients continue to be offered RT alone. Here, we present long-term follow-up of 377 adults of all ages treated with RT alone for early-stage diffuse large-cell lymphoma on British National Lymphoma Investigation trials between 1974 and 1997. 10-year cause-specific survival in patients older than 60 years was poor and significantly inferior to that in younger patients (47 and 75% respectively; P<0.001). There is growing evidence that short-course chemotherapy, with or without RT, is superior to RT alone in early-stage aggressive NHL, in elderly as well as in younger patients. Increased age alone should not exclude patients from systemic treatment for early-stage aggressive NHL.

Item Type: Article
Additional Information: This is a BJC OPEN article which is made available under a Creative Commons Attribution-Non commercial-Share Alike 3.0 Unported licence 12 months after the date of publication. For more information please see http://creativecommons.org/licenses/by-nc-sa/3.0/
Keywords: Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Female, Follow-Up Studies, Humans, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Non-Hodgkin, Male, Middle Aged, Neoplasm Staging, Prognosis, Retrospective Studies, Treatment Outcome, Science & Technology, Life Sciences & Biomedicine, Oncology, aggressive lymphoma, non-Hodgkin's lymphoma, old age, radiotherapy, LARGE-CELL LYMPHOMA, HEMATOPOIETIC GROWTH-FACTORS, COMBINED-MODALITY TREATMENT, COLONY-STIMULATING FACTOR, RADIATION-THERAPY, LOCALIZED INTERMEDIATE, PROGNOSTIC FACTORS, ELDERLY-PATIENTS, CHEMOTHERAPY, IRRADIATION, aggressive lymphoma, non-Hodgkin's lymphoma, old age, radiotherapy
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: BRITISH JOURNAL OF CANCER
ISSN: 0007-0920
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Dates:
DateEvent
22 March 2004Published
Web of Science ID: WOS:000220846900009
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URI: https://openaccess.sgul.ac.uk/id/eprint/102321
Publisher's version: https://doi.org/10.1038/sj.bjc.6601675

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