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Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.

Tradtrantip, L; Zhang, H; Saadoun, S; Phuan, PW; Lam, C; Papadopoulos, MC; Bennett, JL; Verkman, AS (2012) Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Ann Neurol, 71 (3). 314 - 322. https://doi.org/10.1002/ana.22657
SGUL Authors: Papadopoulos, Marios Saadoun, Samira

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Abstract

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system. Circulating autoantibodies (NMO-immunoglobulin [Ig]G) against astrocyte water channel aquaporin-4 (AQP4) cause complement- and cell-mediated astrocyte damage with consequent neuroinflammation and demyelination. Current NMO therapies, which have limited efficacy, include immunosuppression and plasma exchange. The objective of this study was to develop a potential new NMO therapy based on blocking of pathogenic NMO-IgG binding to its target, AQP4.

Item Type: Article
Additional Information: PMCID: PMC3314396
Keywords: Animals, Animals, Newborn, Antibodies, Monoclonal, Aquaporin 4, Binding Sites, Antibody, Binding, Competitive, CHO Cells, Cells, Cultured, Cricetinae, Cricetulus, Humans, Immunoglobulin G, Mice, Mice, Knockout, Neuromyelitis Optica, Organ Culture Techniques, Protein Binding, Recombinant Proteins
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Neuroscience (INCCNS)
Journal or Publication Title: Ann Neurol
Dates:
DateEvent
March 2012Published
PubMed ID: 22271321
Web of Science ID: 22271321
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URI: https://openaccess.sgul.ac.uk/id/eprint/101645
Publisher's version: https://doi.org/10.1002/ana.22657

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