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Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk.

Couch, FJ; Wang, X; McGuffog, L; Lee, A; Olswold, C; Kuchenbaecker, KB; Soucy, P; Fredericksen, Z; Barrowdale, D; Dennis, J; et al. Couch, FJ; Wang, X; McGuffog, L; Lee, A; Olswold, C; Kuchenbaecker, KB; Soucy, P; Fredericksen, Z; Barrowdale, D; Dennis, J; Gaudet, MM; Dicks, E; Kosel, M; Healey, S; Sinilnikova, OM; Lee, A; Bacot, F; Vincent, D; Hogervorst, FB; Peock, S; Stoppa-Lyonnet, D; Jakubowska, A; kConFab Investigators; Radice, P; Schmutzler, RK; SWE-BRCA; Domchek, SM; Piedmonte, M; Singer, CF; Friedman, E; Thomassen, M; Ontario Cancer Genetics Network; Hansen, TV; Neuhausen, SL; Szabo, CI; Blanco, I; Greene, MH; Karlan, BY; Garber, J; Phelan, CM; Weitzel, JN; Montagna, M; Olah, E; Andrulis, IL; Godwin, AK; Yannoukakos, D; Goldgar, DE; Caldes, T; Nevanlinna, H; Osorio, A; Terry, MB; Daly, MB; van Rensburg, EJ; Hamann, U; Ramus, SJ; Toland, AE; Caligo, MA; Olopade, OI; Tung, N; Claes, K; Beattie, MS; Southey, MC; Imyanitov, EN; Tischkowitz, M; Janavicius, R; John, EM; Kwong, A; Diez, O; Balmaña, J; Barkardottir, RB; Arun, BK; Rennert, G; Teo, SH; Ganz, PA; Campbell, I; van der Hout, AH; van Deurzen, CH; Seynaeve, C; Gómez Garcia, EB; van Leeuwen, FE; Meijers-Heijboer, HE; Gille, JJ; Ausems, MG; Blok, MJ; Ligtenberg, MJ; Rookus, MA; Devilee, P; Verhoef, S; van Os, TA; Wijnen, JT; HEBON; EMBRACE; Frost, D; Ellis, S; Fineberg, E; Platte, R; Evans, DG; Izatt, L; Eeles, RA; Adlard, J; Eccles, DM; Cook, J; Brewer, C; Douglas, F; Hodgson, S; Morrison, PJ; Side, LE; Donaldson, A; Houghton, C; Rogers, MT; Dorkins, H; Eason, J; Gregory, H; McCann, E; Murray, A; Calender, A; Hardouin, A; Berthet, P; Delnatte, C; Nogues, C; Lasset, C; Houdayer, C; Leroux, D; Rouleau, E; Prieur, F; Damiola, F; Sobol, H; Coupier, I; Venat-Bouvet, L; Castera, L; Gauthier-Villars, M; Léoné, M; Pujol, P; Mazoyer, S; Bignon, YJ; GEMO Study Collaborators; Złowocka-Perłowska, E; Gronwald, J; Lubinski, J; Durda, K; Jaworska, K; Huzarski, T; Spurdle, AB; Viel, A; Peissel, B; Bonanni, B; Melloni, G; Ottini, L; Papi, L; Varesco, L; Tibiletti, MG; Peterlongo, P; Volorio, S; Manoukian, S; Pensotti, V; Arnold, N; Engel, C; Deissler, H; Gadzicki, D; Gehrig, A; Kast, K; Rhiem, K; Meindl, A; Niederacher, D; Ditsch, N; Plendl, H; Preisler-Adams, S; Engert, S; Sutter, C; Varon-Mateeva, R; Wappenschmidt, B; Weber, BH; Arver, B; Stenmark-Askmalm, M; Loman, N; Rosenquist, R; Einbeigi, Z; Nathanson, KL; Rebbeck, TR; Blank, SV; Cohn, DE; Rodriguez, GC; Small, L; Friedlander, M; Bae-Jump, VL; Fink-Retter, A; Rappaport, C; Gschwantler-Kaulich, D; Pfeiler, G; Tea, MK; Lindor, NM; Kaufman, B; Shimon Paluch, S; Laitman, Y; Skytte, AB; Gerdes, AM; Pedersen, IS; Moeller, ST; Kruse, TA; Jensen, UB; Vijai, J; Sarrel, K; Robson, M; Kauff, N; Mulligan, AM; Glendon, G; Ozcelik, H; Ejlertsen, B; Nielsen, FC; Jønson, L; Andersen, MK; Ding, YC; Steele, L; Foretova, L; Teulé, A; Lazaro, C; Brunet, J; Pujana, MA; Mai, PL; Loud, JT; Walsh, C; Lester, J; Orsulic, S; Narod, SA; Herzog, J; Sand, SR; Tognazzo, S; Agata, S; Vaszko, T; Weaver, J; Stavropoulou, AV; Buys, SS; Romero, A; de la Hoya, M; Aittomäki, K; Muranen, TA; Duran, M; Chung, WK; Lasa, A; Dorfling, CM; Miron, A; BCFR; Benitez, J; Senter, L; Huo, D; Chan, SB; Sokolenko, AP; Chiquette, J; Tihomirova, L; Friebel, TM; Agnarsson, BA; Lu, KH; Lejbkowicz, F; James, PA; Hall, P; Dunning, AM; Tessier, D; Cunningham, J; Slager, SL; Wang, C; Hart, S; Stevens, K; Simard, J; Pastinen, T; Pankratz, VS; Offit, K; Easton, DF; Chenevix-Trench, G; Antoniou, AC; CIMBA (2013) Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk. PLOS GENETICS, 9 (3). e1003212. ISSN 1553-7404 https://doi.org/10.1371/journal.pgen.1003212
SGUL Authors: Hodgson, Shirley Victoria

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Abstract

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7 × 10(-8), HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4 × 10(-8), HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4 × 10(-8), HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific association. The 17q21.31 locus was also associated with ovarian cancer risk in 8,211 BRCA2 carriers (P = 2×10(-4)). These loci may lead to an improved understanding of the etiology of breast and ovarian tumors in BRCA1 carriers. Based on the joint distribution of the known BRCA1 breast cancer risk-modifying loci, we estimated that the breast cancer lifetime risks for the 5% of BRCA1 carriers at lowest risk are 28%-50% compared to 81%-100% for the 5% at highest risk. Similarly, based on the known ovarian cancer risk-modifying loci, the 5% of BRCA1 carriers at lowest risk have an estimated lifetime risk of developing ovarian cancer of 28% or lower, whereas the 5% at highest risk will have a risk of 63% or higher. Such differences in risk may have important implications for risk prediction and clinical management for BRCA1 carriers.

Item Type: Article
Additional Information: ©2013 Couch et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: BRCA1 Protein, BRCA2 Protein, Breast Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Heterozygote, Humans, Middle Aged, Mutation, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Prognosis, Risk Factors, Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, COMMON VARIANTS, SUSCEPTIBILITY ALLELES, GENETIC-VARIANTS, MODIFIERS, INVESTIGATORS, POPULATION, CONSORTIUM, SELECTION, SUBTYPES, ZNF365
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS)
Journal or Publication Title: PLOS GENETICS
ISSN: 1553-7404
Dates:
DateEvent
27 March 2013Published
Web of Science ID: WOS:000316866700002
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URI: https://openaccess.sgul.ac.uk/id/eprint/101286
Publisher's version: https://doi.org/10.1371/journal.pgen.1003212

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