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Sylvia Haas, Hugo ten Cate, Gabriele Accetta, Pantep Angchaisuksiri, Jean-Pierre Bassand, A. John Camm, Ramon Corbalan, Harald Darius, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Barry Jacobson, Gloria Kayani, Lorenzo G. Mantovani, Frank Misselwitz, Karen Pieper, Sebastian M. Schellong, Janina Stepinska, Alexander G. G. Turpie, Martin van Eickels, Ajay K. Kakkar, for the GARFIELD-AF Investigators
Quality of Vitamin K Antagonist Control and 1-Year Outcomes in Patients with Atrial Fibrillation: A Global Perspective from the GARFIELD-AF Registry
www.plosone.org
www.plosone.org
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ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
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f*
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Q
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454.0136 340.3911 l
453.5135 340.8911 l
453.5135 352.891 l
f*
454.0136 340.3911 m
403.7777 340.3911 l
403.7777 340.8911 l
453.5135 340.8911 l
f*
526.2633 352.891 m
526.2633 340.3911 l
525.7633 340.8911 l
525.7633 352.891 l
f*
526.2633 340.3911 m
454.0136 340.3911 l
454.0136 340.8911 l
525.7633 340.8911 l
f*
575.9991 340.3911 m
526.2633 340.3911 l
526.2633 340.8911 l
575.9991 340.8911 l
f*
575.9991 282.6411 m
36 282.6411 l
36 283.1411 l
575.9991 283.1411 l
f*
0 g
1 j
1 J
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(Table)Tj
2.8275 0 Td
(1.)Tj
1.2685 0 Td
(Baseline)Tj
4.3087 0 Td
(characteristi)Tj
5.9103 0 Td
(cs)Tj
1.3252 0 Td
(of)Tj
1.1622 0 Td
(patients)Tj
4.0394 0 Td
(according)Tj
4.9891 0 Td
(to)Tj
1.1622 0 Td
(proportio)Tj
4.4433 0 Td
(n)Tj
0.8362 0 Td
(of)Tj
1.1623 0 Td
(time)Tj
2.2677 0 Td
(in)Tj
1.1126 0 Td
(therapeu)Tj
4.2024 0 Td
(tic)Tj
1.389 0 Td
(range.)Tj
-19.5238 -1.8567 Td
(TTR)Tj
/F13 1 Tf
[( )]TJ
/F2 1 Tf
(65%)Tj
4.741 0 Td
(\(N)Tj
1.2756 0 Td
(=)Tj
0.815 0 Td
(5851;)Tj
2.7638 0 Td
(58.9%\))Tj
5.6268 0 Td
(TTR)Tj
/F10 1 Tf
()Tj
/F2 1 Tf
(65%)Tj
4.9252 0 Td
(\(N)Tj
1.2756 0 Td
(=)Tj
0.815 0 Td
(4083;)Tj
2.7567 0 Td
(41.1%\))Tj
6.8315 0 Td
(Total)Tj
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(\(N)Tj
1.2827 0 Td
(=)Tj
0.8079 0 Td
(9934;)Tj
2.7638 0 Td
(100%\))Tj
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-62.1784 -1.6228 Td
(Age,)Tj
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(mean)Tj
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(\(SD\),)Tj
2.5512 0 Td
(years)Tj
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(\(10.6\))Tj
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(71.9)Tj
2.1614 0 Td
(\(9.7\))Tj
12.8694 0 Td
(71.2)Tj
2.1614 0 Td
(\(10.2\))Tj
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(Age)Tj
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(group,)Tj
3.0402 0 Td
(n/N,)Tj
2.0551 0 Td
(%)Tj
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(6574)Tj
2.9764 0 Td
(years)Tj
19.8001 0 Td
(2029/58)Tj
3.5788 0 Td
(51)Tj
5.4496 0 Td
(34.7)Tj
6.2788 0 Td
(1430/408)Tj
4.1316 0 Td
(3)Tj
4.9039 0 Td
(35.0)Tj
6.2788 0 Td
(3459/99)Tj
3.5788 0 Td
(34)Tj
5.4496 0 Td
(34.8)Tj
/F10 1 Tf
-62.4264 -1.5591 Td
()Tj
/F0 1 Tf
(75)Tj
2.0976 0 Td
(years)Tj
20.6789 0 Td
(2343/58)Tj
3.5788 0 Td
(51)Tj
5.4496 0 Td
(40.0)Tj
6.2788 0 Td
(1786/408)Tj
4.1316 0 Td
(3)Tj
4.9039 0 Td
(43.7)Tj
6.2788 0 Td
(4129/99)Tj
3.5788 0 Td
(34)Tj
5.4496 0 Td
(41.6)Tj
-63.4256 -1.5661 Td
(Women,)Tj
3.9401 0 Td
(n/N,)Tj
2.0552 0 Td
(%)Tj
17.7804 0 Td
(2649/58)Tj
3.5788 0 Td
(51)Tj
5.4496 0 Td
(45.3)Tj
6.2788 0 Td
(1791/408)Tj
4.1316 0 Td
(3)Tj
4.9039 0 Td
(43.9)Tj
6.2788 0 Td
(4440/99)Tj
3.5788 0 Td
(34)Tj
5.4496 0 Td
(44.7)Tj
-63.4256 -1.5591 Td
(BMI)Tj
2.0055 0 Td
(category,)Tj
4.3228 0 Td
(n/N,)Tj
2.0552 0 Td
(%)Tj
/F6 1 Tf
-7.3843 -1.5662 Td
[( )]TJ
/F0 1 Tf
(19)Tj
1.9063 0 Td
(kg/m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 76.5354 609.4488 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 228.359 605.8771 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(109/4594)Tj
9.3118 0 Td
(2.4)Tj
6.2788 0 Td
(40/3137)Tj
9.0284 0 Td
(1.3)Tj
6.0025 0 Td
(149/7731)Tj
9.3118 0 Td
(1.9)Tj
-62.9791 -1.559 Td
(19)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(25)Tj
3.5575 0 Td
(kg/m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 89.7448 596.9196 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 226.2047 593.4047 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(1390/45)Tj
3.5787 0 Td
(94)Tj
5.4497 0 Td
(30.3)Tj
6.5551 0 Td
(771/3137)Tj
8.7592 0 Td
(24.6)Tj
6.2788 0 Td
(2161/77)Tj
3.5787 0 Td
(31)Tj
5.4497 0 Td
(28.0)Tj
-62.4264 -1.5661 Td
(25)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(30)Tj
3.5575 0 Td
(kg/m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 89.7448 584.4472 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 226.2047 580.8755 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(1715/45)Tj
3.5787 0 Td
(94)Tj
5.4497 0 Td
(37.3)Tj
6.2788 0 Td
(1245/313)Tj
4.1315 0 Td
(7)Tj
4.904 0 Td
(39.7)Tj
6.2788 0 Td
(2960/77)Tj
3.5787 0 Td
(31)Tj
5.4497 0 Td
(38.3)Tj
-62.4264 -1.559 Td
(30)Tj
/F6 1 Tf
[( )]TJ
/F0 1 Tf
(40)Tj
3.5575 0 Td
(kg/m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 89.7448 571.9181 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 226.2047 568.4031 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(1214/45)Tj
3.5787 0 Td
(94)Tj
5.4497 0 Td
(26.4)Tj
6.5551 0 Td
(973/3137)Tj
8.7592 0 Td
(31.0)Tj
6.2788 0 Td
(2187/77)Tj
3.5787 0 Td
(31)Tj
5.4497 0 Td
(28.3)Tj
/F10 1 Tf
-62.4264 -1.5661 Td
()Tj
/F0 1 Tf
(40)Tj
2.0976 0 Td
(kg/m)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 78.0661 559.4456 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 228.359 555.874 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(166/4594)Tj
9.3118 0 Td
(3.6)Tj
6.0024 0 Td
(108/3137)Tj
9.3048 0 Td
(3.4)Tj
6.0025 0 Td
(274/7731)Tj
9.3118 0 Td
(3.5)Tj
-63.9783 -1.559 Td
(Medical)Tj
3.6496 0 Td
(history,)Tj
3.437 0 Td
(n/N,)Tj
2.0552 0 Td
(%)Tj
-8.1426 -1.5662 Td
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2.9126 0 Td
(stive)Tj
2.2819 0 Td
(heart)Tj
2.4874 0 Td
(failure)Tj
15.0947 0 Td
(1189/58)Tj
3.5786 0 Td
(51)Tj
5.4497 0 Td
(20.3)Tj
6.5551 0 Td
(673/4083)Tj
8.7592 0 Td
(16.5)Tj
6.2788 0 Td
(1862/99)Tj
3.5787 0 Td
(34)Tj
5.4497 0 Td
(18.7)Tj
-62.4264 -1.559 Td
(History)Tj
3.3236 0 Td
(of)Tj
1.056 0 Td
(hypertensio)Tj
5.1307 0 Td
(n)Tj
13.2663 0 Td
(4574/58)Tj
3.5786 0 Td
(42)Tj
5.4497 0 Td
(78.3)Tj
6.2788 0 Td
(3283/407)Tj
4.1315 0 Td
(3)Tj
4.904 0 Td
(80.6)Tj
6.2788 0 Td
(7857/99)Tj
3.5787 0 Td
(15)Tj
5.4497 0 Td
(79.2)Tj
-62.4264 -1.5662 Td
(Diabetes)Tj
4.1457 0 Td
(mellitus)Tj
18.6309 0 Td
(1490/58)Tj
3.5786 0 Td
(51)Tj
5.4497 0 Td
(25.5)Tj
6.5551 0 Td
(888/4083)Tj
8.7592 0 Td
(21.7)Tj
6.2788 0 Td
(2378/99)Tj
3.5787 0 Td
(34)Tj
5.4497 0 Td
(23.9)Tj
-62.4264 -1.5591 Td
(Prior)Tj
2.3244 0 Td
(stroke/trans)Tj
5.2016 0 Td
(ient)Tj
1.8284 0 Td
(ischaemic)Tj
4.6489 0 Td
(attack)Tj
9.0425 0 Td
(751/5851)Tj
8.7591 0 Td
(12.8)Tj
6.5551 0 Td
(583/4083)Tj
8.7592 0 Td
(14.3)Tj
6.2788 0 Td
(1334/99)Tj
3.5787 0 Td
(34)Tj
5.4497 0 Td
(13.4)Tj
-62.4264 -1.5661 Td
(Vascular)Tj
4.089 0 Td
(disease)Tj
/F4 1 Tf
[()]TJ
/F0 1 Tf
18.9568 0 Td
(814/5842)Tj
8.7591 0 Td
(13.9)Tj
6.5551 0 Td
(608/4077)Tj
8.7592 0 Td
(14.9)Tj
6.2788 0 Td
(1422/99)Tj
3.5787 0 Td
(19)Tj
5.4497 0 Td
(14.3)Tj
-62.4264 -1.5591 Td
(Chroni)Tj
2.9126 0 Td
(c)Tj
0.7299 0 Td
(kidney)Tj
3.0969 0 Td
(disease)Tj
3.6497 0 Td
(\(Grade)Tj
/F10 1 Tf
3.3236 0 Td
()Tj
/F0 1 Tf
(3\))Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 166.9039 471.9685 cm
BT
/F0 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 228.359 468.3968 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(749/5851)Tj
8.7591 0 Td
(12.8)Tj
6.5551 0 Td
(522/4083)Tj
8.7592 0 Td
(12.8)Tj
6.2788 0 Td
(1271/99)Tj
3.5787 0 Td
(34)Tj
5.4497 0 Td
(12.8)Tj
-62.4264 -1.5661 Td
(History)Tj
3.3236 0 Td
(of)Tj
1.056 0 Td
(bleeding)Tj
18.6662 0 Td
(121/5838)Tj
9.3118 0 Td
(2.1)Tj
6.2788 0 Td
(70/4077)Tj
9.0284 0 Td
(1.7)Tj
6.0025 0 Td
(191/9915)Tj
9.3118 0 Td
(1.9)Tj
-63.9783 -1.5591 Td
(Alcohol)Tj
3.4795 0 Td
(consumpt)Tj
4.3087 0 Td
(ion,)Tj
1.8284 0 Td
(n/N,)Tj
2.0622 0 Td
(%)Tj
-10.6796 -1.5661 Td
(Abstinent)Tj
22.7766 0 Td
(2585/49)Tj
3.5786 0 Td
(43)Tj
5.4497 0 Td
(52.3)Tj
6.2788 0 Td
(1544/334)Tj
4.1315 0 Td
(6)Tj
4.904 0 Td
(46.1)Tj
6.2788 0 Td
(4129/82)Tj
3.5787 0 Td
(89)Tj
5.4497 0 Td
(49.8)Tj
-62.4264 -1.5591 Td
(Light)Tj
22.7766 0 Td
(1701/49)Tj
3.5786 0 Td
(43)Tj
5.4497 0 Td
(34.4)Tj
6.2788 0 Td
(1427/334)Tj
4.1315 0 Td
(6)Tj
4.904 0 Td
(42.6)Tj
6.2788 0 Td
(3128/82)Tj
3.5787 0 Td
(89)Tj
5.4497 0 Td
(37.7)Tj
-62.4264 -1.5661 Td
(Modera)Tj
3.3591 0 Td
(te)Tj
19.6867 0 Td
(521/4943)Tj
8.7591 0 Td
(10.5)Tj
6.5551 0 Td
(323/3346)Tj
9.3048 0 Td
(9.7)Tj
6.0025 0 Td
(844/8289)Tj
8.7591 0 Td
(10.2)Tj
-62.4264 -1.5591 Td
(Heavy)Tj
23.0458 0 Td
(136/4943)Tj
9.3118 0 Td
(2.8)Tj
6.2788 0 Td
(52/3346)Tj
9.0284 0 Td
(1.6)Tj
6.0025 0 Td
(188/8289)Tj
9.3118 0 Td
(2.3)Tj
-63.9783 -1.5662 Td
(Smoker,)Tj
3.9402 0 Td
(n/N,)Tj
2.0551 0 Td
(%)Tj
-4.9961 -1.559 Td
(No)Tj
22.7766 0 Td
(3329/52)Tj
3.5786 0 Td
(77)Tj
5.4497 0 Td
(63.1)Tj
6.2788 0 Td
(2332/367)Tj
4.1315 0 Td
(1)Tj
4.904 0 Td
(63.5)Tj
6.2788 0 Td
(5661/89)Tj
3.5787 0 Td
(48)Tj
5.4497 0 Td
(63.3)Tj
-62.4264 -1.5591 Td
(Ex-smok)Tj
3.8693 0 Td
(er)Tj
18.9073 0 Td
(1411/52)Tj
3.5786 0 Td
(77)Tj
5.4497 0 Td
(26.7)Tj
6.2788 0 Td
(1055/367)Tj
4.1315 0 Td
(1)Tj
4.904 0 Td
(28.7)Tj
6.2788 0 Td
(2466/89)Tj
3.5787 0 Td
(48)Tj
5.4497 0 Td
(27.6)Tj
-62.4264 -1.5662 Td
(Current)Tj
3.5433 0 Td
(smoker)Tj
19.5025 0 Td
(537/5277)Tj
8.7591 0 Td
(10.2)Tj
6.5551 0 Td
(284/3671)Tj
9.3048 0 Td
(7.7)Tj
6.0025 0 Td
(821/8948)Tj
9.3118 0 Td
(9.2)Tj
/F4 1 Tf
-63.9783 -2.3456 Td
[()]TJ
/F0 1 Tf
(Periphera)Tj
4.8473 0 Td
(l)Tj
0.4535 0 Td
(artery)Tj
2.7709 0 Td
(disease)Tj
3.6425 0 Td
(or)Tj
1.1197 0 Td
(corona)Tj
3.026 0 Td
(ry)Tj
1.063 0 Td
(artery)Tj
2.7709 0 Td
(disease)Tj
3.6497 0 Td
(with)Tj
1.9983 0 Td
(a)Tj
0.7795 0 Td
(history)Tj
3.1536 0 Td
(of)Tj
1.063 0 Td
(acute)Tj
2.6575 0 Td
(coronary)Tj
4.0961 0 Td
(syndrome)Tj
4.3583 0 Td
(s.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 316.1763 cm
BT
/F0 1 Tf
1 TL
0 0 Td
()Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 39.2881 312.6614 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Renal)Tj
2.8204 0 Td
(function)Tj
3.7064 0 Td
(was)Tj
1.9984 0 Td
(assess)Tj
3.0898 0 Td
(ed)Tj
1.3323 0 Td
(according)Tj
4.5284 0 Td
(to)Tj
1.063 0 Td
(the)Tj
1.6087 0 Td
(National)Tj
3.8622 0 Td
(Kidney)Tj
3.2669 0 Td
(Founda)Tj
3.3591 0 Td
(tion's)Tj
2.5512 0 Td
(Kidney)Tj
3.2599 0 Td
(Disease)Tj
3.8126 0 Td
(Outcomes)Tj
4.7694 0 Td
(Quality)Tj
3.3236 0 Td
(Initiativ)Tj
3.0898 0 Td
(e)Tj
0.7866 0 Td
(classic)Tj
3.4725 0 Td
(ation)Tj
2.3811 0 Td
(by)Tj
1.2827 0 Td
(investig)Tj
3.3591 0 Td
(ators)Tj
2.4449 0 Td
(at)Tj
-65.58 -1.5023 Td
(baseline.)Tj
0 -1.5024 Td
(BMI,)Tj
2.2889 0 Td
(body)Tj
2.3741 0 Td
(mass)Tj
2.6078 0 Td
(index;)Tj
2.8772 0 Td
(SD,)Tj
1.8922 0 Td
(standard)Tj
4.0961 0 Td
(deviation;)Tj
4.4787 0 Td
(TTR,)Tj
2.452 0 Td
(time)Tj
2.1048 0 Td
(in)Tj
0.9992 0 Td
(therapeutic)Tj
5.1449 0 Td
(range.)Tj
/F8 1 Tf
-31.3159 -2.2465 Td
(doi:)Tj
-0.025 Tc
(10.13)Tj
3.5787 0 Td
(71/journal.pone)Tj
5.804 0 Td
(.0164076.t001)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
200.0001 240.7521 m
576 240.7521 l
576 240.2521 l
200.0001 240.2521 l
f*
298.5489 240.2521 m
298.5489 227.2521 l
298.0488 227.7522 l
298.0488 240.2521 l
f*
298.5489 227.2521 m
200.0001 227.2521 l
200.0001 227.7522 l
298.0488 227.7522 l
f*
437.5242 240.2521 m
437.5242 227.2521 l
437.0241 227.7522 l
437.0241 240.2521 l
f*
437.5242 227.2521 m
298.5489 227.2521 l
298.5489 227.7522 l
437.0241 227.7522 l
f*
575.9994 227.2521 m
437.5242 227.2521 l
437.5242 227.7522 l
575.9994 227.7522 l
f*
298.5489 227.2521 m
298.5489 214.7522 l
298.0488 215.2522 l
298.0488 227.2521 l
f*
298.5489 214.7522 m
200.0001 214.7522 l
200.0001 215.2522 l
298.0488 215.2522 l
f*
379.0434 227.2521 m
379.0434 214.7522 l
378.5434 215.2522 l
378.5434 227.2521 l
f*
379.0434 214.7522 m
298.5489 214.7522 l
298.5489 215.2522 l
378.5434 215.2522 l
f*
437.5242 227.2521 m
437.5242 214.7522 l
437.0241 215.2522 l
437.0241 227.2521 l
f*
437.5242 214.7522 m
379.0434 214.7522 l
379.0434 215.2522 l
437.0241 215.2522 l
f*
518.0187 227.2521 m
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ET
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BT
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[()-11()1()7()5()]TJ
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[()11()5()6()1()2()-3()18()-5()2(\n)11()]TJ
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[(\n)11()12()6()-1(\n)11()4()2()]TJ
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[()13()5()-2()18()6()-6()]TJ
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[(\()10()-2()-4()1()12()-2()]TJ
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[()-1(\n)11()19()-5()13(\n)6()6($)]TJ
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[(\))1()4()]TJ
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[()8()3()-4()7()1()2()3()]TJ
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[()1()4()6()12()2()2()2()]TJ
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[()10(\r)44()-5()13()-5()18()6()-6()]TJ
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[()-5()18()-5()2()1()19()]TJ
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[()-3()12()-4()]TJ
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36 703.8893 m
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143.2534 665.3894 m
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f*
235.4927 665.3894 m
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235.4927 652.8895 m
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307.8655 665.3894 m
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307.8655 652.8895 m
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f*
375.3371 652.8895 m
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454.8538 665.3894 m
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454.8538 652.8895 m
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575.9994 652.8895 m
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143.2534 652.8895 m
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f*
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f*
235.4927 652.8895 m
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f*
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f*
307.8655 652.8895 m
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f*
307.8655 640.3895 m
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f*
375.3371 652.8895 m
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374.8371 640.8896 l
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f*
375.3371 640.3895 m
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f*
454.8538 652.8895 m
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f*
454.8538 640.3895 m
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f*
575.9994 640.3895 m
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f*
575.9994 606.6394 m
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575.9994 607.1394 l
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0 g
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BT
/F2 1 Tf
1 TL
0 0 Td
(Table)Tj
2.8275 0 Td
(3.)Tj
1.2685 0 Td
(Proportion)Tj
5.3292 0 Td
(of)Tj
1.1622 0 Td
(time)Tj
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(therapeuti)Tj
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(c)Tj
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(\(%\))Tj
1.7716 0 Td
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(patients)Tj
4.0394 0 Td
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1.4457 0 Td
(different)Tj
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(vitamin)Tj
3.7063 0 Td
(K)Tj
0.9425 0 Td
(antago)Tj
3.267 0 Td
(nists)Tj
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( \r)Tj
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(.)Tj
-43.4129 -1.8567 Td
(VKA)Tj
2.3244 0 Td
(therapy)Tj
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(n)Tj
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(Interquarti)Tj
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(le)Tj
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(Warfarin)Tj
16.6253 0 Td
(6513)Tj
2.4307 0 Td
(\(66.7\))Tj
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(55.4)Tj
8.745 0 Td
(28.4)Tj
9.1843 0 Td
(60.8)Tj
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2.1614 0 Td
(to)Tj
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(arol)Tj
11.3812 0 Td
(2345)Tj
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(\(24.0\))Tj
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(23.7)Tj
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2.1614 0 Td
(to)Tj
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(Phenproc)Tj
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(oumon)Tj
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2.1614 0 Td
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(=)Tj
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(SD,)Tj
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(standard)Tj
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(deviation;)Tj
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(VKA,)Tj
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(vitamin)Tj
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(antagonist)Tj
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(doi:)Tj
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(10.13)Tj
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(71/journal.pone)Tj
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ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 155.2527 m
576 155.2527 l
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f*
120.7542 154.7527 m
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f*
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449.8534 142.2527 l
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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f*
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449.8534 117.2529 l
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f*
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f*
575.9989 95.0026 m
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575.9989 95.5026 l
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BT
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(4.)Tj
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