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Relation of Helicobacter pylori infection and coronary heart disease.

Mendall, MA; Goggin, PM; Molineaux, N; Levy, J; Toosy, T; Strachan, D; Camm, AJ; Northfield, TC (1994) Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J, 71 (5). 437 - 439. ISSN 0007-0769 https://doi.org/10.1136/hrt.71.5.437
SGUL Authors: Camm, Alan John Strachan, David Peter

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Abstract

BACKGROUND--There is evidence suggesting that early life experience may influence adult risk of coronary heart disease (CHD). Chronic bacterial infections have been associated with CHD. OBJECTIVE--To determine whether Helicobacter pylori, a childhood acquired chronic bacterial infection, is associated with an increased risk of coronary heart disease in later life. DESIGN--Case-control study controlling for potential confounding variables with an opportunistically recruited control group. SUBJECTS--111 consecutive cases with documented CHD were recruited from a cardiology clinic and 74 controls from a general practice health screening clinic. All were white men aged 45-65. METHODS--Serum was analysed for the presence of H pylori specific IgG antibodies by ELISA (98% sensitive and 94% specific for the presence of infection). RESULTS--59% of the cases and 39% of the controls were seropositive for H pylori (odds ratio 2.28, chi 2 7.35, p = 0.007). After adjustment by multiple logistic regression for age, cardiovascular risk factors, and current social class, the effect of H pylori was little altered (odds ratio 2.15, p = 0.03). Further adjustment for various features of the childhood environment known to be risk factors for H pylori infection only slightly weakened the association (odds ratio 1.9). H pylori seropositivity was not related to the level of risk factors in the control population. CONCLUSION--In this pilot study the association of adult coronary heart disease with H pylori seropositivity suggests that the early childhood environment may be important in determining the risk of CHD in adult life. The association needs confirmation in other better designed studies. If H pylori itself is responsible for the association, then this is of great potential importance as the infection is treatable.

Item Type: Article
Additional Information: PMCID: PMC483719
Keywords: Aged, Antibodies, Bacterial, Chronic Disease, Coronary Disease, Helicobacter Infections, Helicobacter pylori, Humans, Logistic Models, Male, Middle Aged, Poverty, Risk Factors
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Br Heart J
ISSN: 0007-0769
Dates:
DateEvent
1 May 1994Published
PubMed ID: 8011406
Web of Science ID: 8011406
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URI: https://openaccess.sgul.ac.uk/id/eprint/32
Publisher's version: https://doi.org/10.1136/hrt.71.5.437

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