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TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres.

Jones, AM; Beggs, AD; Carvajal-Carmona, L; Farrington, S; Tenesa, A; Walker, M; Howarth, K; Ballereau, S; Hodgson, SV; Zauber, A; et al. Jones, AM; Beggs, AD; Carvajal-Carmona, L; Farrington, S; Tenesa, A; Walker, M; Howarth, K; Ballereau, S; Hodgson, SV; Zauber, A; Bertagnolli, M; Midgley, R; Campbell, H; Kerr, D; Dunlop, MG; Tomlinson, IP (2012) TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. Gut, 61 (2). 248 - 254. https://doi.org/10.1136/gut.2011.239772
SGUL Authors: Hodgson, Shirley Victoria

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Abstract

Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to CRC.

Item Type: Article
Additional Information: PMCID: PMC3245900
Keywords: Adenoma, Aged, Carcinoma, Case-Control Studies, Colorectal Neoplasms, Female, Genetic Predisposition to Disease, Genotyping Techniques, HCT116 Cells, Humans, Leukocytes, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, RNA, Retrospective Studies, Telomerase, Telomere
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS)
Journal or Publication Title: Gut
Dates:
DateEvent
February 2012Published
PubMed ID: 21708826
Web of Science ID: 21708826
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URI: https://openaccess.sgul.ac.uk/id/eprint/1905
Publisher's version: https://doi.org/10.1136/gut.2011.239772

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