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Impact of early life geohelminths on wheeze, asthma, and atopy in Ecuadorian children at 8 years.

Cooper, PJ; Chis Ster, I; Chico, ME; Vaca, M; Oviedo, Y; Maldonado, A; Barreto, ML; Platts-Mills, TA; Strachan, DP (2021) Impact of early life geohelminths on wheeze, asthma, and atopy in Ecuadorian children at 8 years. Allergy, 76 (9). pp. 2765-2775. ISSN 1398-9995 https://doi.org/10.1111/all.14821
SGUL Authors: Strachan, David Peter Cooper, Philip John Chis Ster, Delizia Irina

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Abstract

BACKGROUND: Early-lifeexposures to geohelminths may protect against development of wheeze/asthma and atopy. OBJECTIVE: Study effect of maternal geohelminths and infections in children during the first 5 years on atopy, wheeze/asthma, and airways reactivity/inflammation at 8 years. METHODS: Birth cohort of 2,404 neonates followed to 8 years in rural Ecuador. Data on wheeze/asthma were collected by questionnaire and atopy by skin prick test (SPT) reactivity to 9 allergens. We measured airways reactivity to bronchodilator, fractional exhaled nitric oxide (FeNO), and nasal eosinophilia. Stool samples were examined for geohelminths by microscopy. RESULTS: 1,933 (80.4%) children were evaluated at 8 years. Geohelminths were detected in 45.8% of mothers and 45.5% of children to 5 years. Frequencies of outcomes at 8 years were: wheeze (6.6%), asthma between 5 and 8 years (7.9%), SPT (14.7%), airways reactivity (10%), and elevated FeNO (10.3%) and nasal eosinophilia (9.2%). Any maternal geohelminth was associated with reduced SPT prevalence (OR 0.72).Childhood Trichuris trichiura infectionsduring the first 5 years were associated with reduced wheeze (OR 0.57) but greater parasite burdens with Ascaris lumbricoidesat 5 years were associated with increased wheeze (OR 2.83) and asthma (OR 2.60). Associations between maternal geohelminths and wheeze/asthma were modified by atopy. Parasite-specificeffects on wheeze/asthma and airways reactivity and inflammation were observed in non-atopic children. CONCLUSIONS: Our data provide novel evidence for persistent effects of in utero geohelminth exposures on childhood atopy but highlight the complex nature of the relationship between geohelminths and the airways. Registered as an observational study (ISRCTN41239086).

Item Type: Article
Additional Information: © 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Ecuador, Geohelminths, asthma, atopy, wheeze, 1107 Immunology, Allergy
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Allergy
ISSN: 1398-9995
Language: eng
Dates:
DateEvent
31 August 2021Published
7 April 2021Published Online
1 March 2021Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
088862/Z/09/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 33745189
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/113135
Publisher's version: https://doi.org/10.1111/all.14821

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