SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Duration and Density of Fecal Rotavirus Shedding in Vaccinated Malawian Children With Rotavirus Gastroenteritis.

Bennett, A; Pollock, L; Jere, KC; Pitzer, VE; Lopman, B; Bar-Zeev, N; Iturriza-Gomara, M; Cunliffe, NA (2020) Duration and Density of Fecal Rotavirus Shedding in Vaccinated Malawian Children With Rotavirus Gastroenteritis. J Infect Dis, 222 (12). pp. 2035-2040. ISSN 1537-6613 https://doi.org/10.1093/infdis/jiz612
SGUL Authors: Bennett, Aisleen

[img]
Preview
PDF Published Version
Available under License Creative Commons Attribution.

Download (770kB) | Preview

Abstract

Quantifying rotavirus shedding among vaccinated individuals will aid understanding of vaccine indirect effects. Serial stool samples were collected from 196 children who presented with rotavirus gastroenteritis to health facilities in Blantyre, Malawi, and were tested for rotavirus using a VP6 semi-quantitative, real-time polymerase chain reaction. The median duration of fecal shedding was 28 days (95% CI, 19-28). The median copy numbers for peak shedding were 1.99 × 107 (interquartile range, 3.39 × 106 to 6.37 × 107). The fecal viral load was positively associated with disease severity and negatively associated with serum anti-rotavirus immunoglobin A. High and persistent rotavirus shedding among vaccinated children with breakthrough disease may contribute to ongoing transmission in this setting.

Item Type: Article
Additional Information: © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: rotavirus, shedding, transmission, vaccine effectiveness, 11 Medical and Health Sciences, 06 Biological Sciences, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Infect Dis
ISSN: 1537-6613
Language: eng
Dates:
DateEvent
15 December 2020Published
13 December 2020Published Online
4 December 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
R01 AI112970NIAID NIH HHSUNSPECIFIED
R01 AI125842NIAID NIH HHSUNSPECIFIED
102466/Z/13/AWellcome Trusthttp://dx.doi.org/10.13039/100004440
102464/Z/13/AWellcome Trusthttp://dx.doi.org/10.13039/100004440
091909/Z/10/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
101113/Z/13/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 31834930
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/112882
Publisher's version: https://doi.org/10.1093/infdis/jiz612

Actions (login required)

Edit Item Edit Item