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Implementation of High-Sensitivity and Point-of-Care Cardiac Troponin Assays into Practice: Some Different Thoughts.

Apple, FS; Fantz, CR; Collinson, PO; IFCC Committee on Clinical Application of Cardiac Bio-Markers (2021) Implementation of High-Sensitivity and Point-of-Care Cardiac Troponin Assays into Practice: Some Different Thoughts. Clin Chem, 67 (1). pp. 70-78. ISSN 1530-8561 https://doi.org/10.1093/clinchem/hvaa264
SGUL Authors: Collinson, Paul

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Abstract

BACKGROUND: The primary role of the International Federation of Clinical Chemistry (IFCC) Committee on Clinical Application of Cardiac Bio-Markers (C-CB) is to provide educational materials about cardiac biomarker use, emphasizing high-sensitivity cardiac troponin assays. CONTENT: This mini-review, regarding high-sensitivity cardiac and point-of-care troponin assays, addresses 1) new IFCC C-CB/AACC Academy laboratory practice recommendations; 2) new and updated concepts from the Fourth Universal Definition of Myocardial Infarction; 3) the role of point-of-care assays in practice and research; 4) regulatory challenges concerning point-of-care assays; e) testing in the COVID-19 world. SUMMARY: Implementation of high-sensitivity cardiac troponin assays makes a difference now and into the future in clinical practice and research. Providing point-of-care high-sensitivity cardiac troponin assays and optimizing studies to allow clearance of these assays by regulatory agencies, in a timely fashion, may provide improved patient management and outcomes.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical Chemistry following peer review. The version of record Fred S Apple, Corinne R Fantz, Paul O Collinson, on behalf of the IFCC Committee on Clinical Application of Cardiac Bio-Markers, Implementation of High-Sensitivity and Point-of-Care Cardiac Troponin Assays into Practice: Some Different Thoughts, Clinical Chemistry, Volume 67, Issue 1, January 2021, Pages 70–78 is available online at: https://doi.org/10.1093/clinchem/hvaa264
Keywords: IFCC Committee on Clinical Application of Cardiac Bio-Markers, 1004 Medical Biotechnology, 1101 Medical Biochemistry and Metabolomics, 1103 Clinical Sciences, General Clinical Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Clin Chem
ISSN: 1530-8561
Language: eng
Dates:
DateEvent
January 2021Published
5 December 2020Published Online
12 October 2020Accepted
Publisher License: Publisher's own licence
PubMed ID: 33279984
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/112714
Publisher's version: https://doi.org/10.1093/clinchem/hvaa264

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