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VADER: a variable dose-rate external 137Cs irradiator for internal emitter and low dose rate studies.

Garty, G; Xu, Y; Johnson, GW; Smilenov, LB; Joseph, SK; Pujol-Canadell, M; Turner, HC; Ghandhi, SA; Wang, Q; Shih, R; et al. Garty, G; Xu, Y; Johnson, GW; Smilenov, LB; Joseph, SK; Pujol-Canadell, M; Turner, HC; Ghandhi, SA; Wang, Q; Shih, R; Morton, RC; Cuniberti, DE; Morton, SR; Bueno-Beti, C; Morgan, TL; Caracappa, PF; Laiakis, EC; Fornace, AJ; Amundson, SA; Brenner, DJ (2020) VADER: a variable dose-rate external 137Cs irradiator for internal emitter and low dose rate studies. Sci Rep, 10 (1). p. 19899. ISSN 2045-2322 https://doi.org/10.1038/s41598-020-76941-2
SGUL Authors: Bueno Beti, Carlos

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Abstract

In the long term, 137Cs is probably the most biologically important agent released in many accidental (or malicious) radiation disasters. It can enter the food chain, and be consumed, or, if present in the environment (e.g. from fallout), can provide external irradiation over prolonged times. In either case, due to the high penetration of the energetic γ rays emitted by 137Cs, the individual will be exposed to a low dose rate, uniform, whole body, irradiation. The VADER (VAriable Dose-rate External 137Cs irradiatoR) allows modeling these exposures, bypassing many of the problems inherent in internal emitter studies. Making use of discarded 137Cs brachytherapy seeds, the VADER can provide varying low dose rate irradiations at dose rates of 0.1 to 1.2 Gy/day. The VADER includes a mouse "hotel", designed to allow long term simultaneous residency of up to 15 mice. Two source platters containing ~ 250 mCi each of 137Cs brachytherapy seeds are mounted above and below the "hotel" and can be moved under computer control to provide constant low dose rate or a varying dose rate mimicking 137Cs biokinetics in mouse or man. We present the VADER design and characterization of its performance over 18 months of use.

Item Type: Article
Additional Information: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2020
Keywords: physics.med-ph, physics.med-ph
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Sci Rep
ISSN: 2045-2322
Language: eng
Dates:
DateEvent
16 November 2020Published
3 November 2020Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
U19 AI067773NIAID NIH HHSUNSPECIFIED
PubMed ID: 33199728
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/112688
Publisher's version: https://doi.org/10.1038/s41598-020-76941-2

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