SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Longitudinal diffusion tensor imaging in frontotemporal dementia

Mahoney, CJ; Simpson, IJA; Nicholas, JM; Fletcher, PD; Downey, LE; Golden, HL; Clark, CN; Schmitz, N; Rohrer, JD; Schott, JM; et al. Mahoney, CJ; Simpson, IJA; Nicholas, JM; Fletcher, PD; Downey, LE; Golden, HL; Clark, CN; Schmitz, N; Rohrer, JD; Schott, JM; Zhang, H; Ourselin, S; Warren, JD; Fox, NC (2015) Longitudinal diffusion tensor imaging in frontotemporal dementia. Annals of Neurology, 77 (1). pp. 33-46. ISSN 0364-5134 https://doi.org/10.1002/ana.24296
SGUL Authors: Clark, Camilla Neegaard

[img]
Preview
PDF Published Version
Available under License Creative Commons Attribution.

Download (548kB) | Preview

Abstract

Objective Novel biomarkers for monitoring progression in neurodegenerative conditions are needed. Measurement of microstructural changes in white matter (WM) using diffusion tensor imaging (DTI) may be a useful outcome measure. Here we report trajectories of WM change using serial DTI in a cohort with behavioral variant frontotemporal dementia (bvFTD). Methods Twenty‐three patients with bvFTD (12 having genetic mutations), and 18 age‐matched control participants were assessed using DTI and neuropsychological batteries at baseline and ∼1.3 years later. Baseline and follow‐up DTI scans were registered using a groupwise approach. Annualized rates of change for DTI metrics, neuropsychological measures, and whole brain volume were calculated. DTI metric performances were compared, and sample sizes for potential clinical trials were calculated. Results In the bvFTD group as a whole, rates of change in fractional anisotropy (FA) and mean diffusivity (MD) within the right paracallosal cingulum were greatest (FA: −6.8%/yr, p < 0.001; MD: 2.9%/yr, p = 0.01). MAPT carriers had the greatest change within left uncinate fasciculus (FA: −7.9%/yr, p < 0.001; MD: 10.9%/yr, p < 0.001); sporadic bvFTD and C9ORF72 carriers had the greatest change within right paracallosal cingulum (sporadic bvFTD, FA: −6.7%/yr, p < 0.001; MD: 3.8%/yr, p = 0.001; C9ORF72, FA: −6.8%/yr, p = 0.004). Sample size estimates using FA change were substantially lower than neuropsychological or whole brain measures of change. Interpretation Serial DTI scans may be useful for measuring disease progression in bvFTD, with particular trajectories of WM damage emerging. Sample size calculations suggest that longitudinal DTI may be a useful biomarker in future clinical trials.

Item Type: Article
Additional Information: © 2014 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Neurology & Neurosurgery, 1103 Clinical Sciences, 1109 Neurosciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Annals of Neurology
ISSN: 0364-5134
Language: en
Dates:
DateEvent
10 January 2015Published
17 November 2014Published Online
11 October 2014Accepted
Publisher License: Creative Commons: Attribution 3.0
Projects:
Project IDFunderFunder ID
091673/Z/10/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
EP/H046410/1Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/J020990/1Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
EP/K005278Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
MR/J01107X/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
FP7‐ICT‐2011‐9‐601055Seventh Framework Programmehttp://dx.doi.org/10.13039/501100004963
URI: https://openaccess.sgul.ac.uk/id/eprint/112268
Publisher's version: https://doi.org/10.1002/ana.24296

Actions (login required)

Edit Item Edit Item