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Adverse perinatal outcome and placental abnormalities in pregnancies with major fetal congenital heart defects: A retrospective case‐control study

Giorgione, V; Fesslova, V; Boveri, S; Candiani, M; Khalil, A; Cavoretto, P (2020) Adverse perinatal outcome and placental abnormalities in pregnancies with major fetal congenital heart defects: A retrospective case‐control study. Prenat Diagn, 40 (11). pp. 1390-1397. ISSN 1097-0223 https://doi.org/10.1002/pd.5770
SGUL Authors: Khalil, Asma

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Abstract

Objective The placental development has been shown to be compromised in pregnancies affected by fetal congenital heart defects (CHD). This study aimed to investigate the frequency of complications related to utero‐placental insufficiency in pregnancies with and without major CHD. Method This retrospective case‐control study was conducted at a Fetal Echocardiography Center in Milan. The following outcomes were compared between the two groups: preeclampsia (PE), small for gestational age (SGA), placental disorders and preterm birth (PTB). The logistic regression analysis was adjusted for maternal age, parity, co‐morbidities and mode of conception. Results The CHD group (n = 480) showed significantly increased incidence of PE (2.9% vs 0.9%; aOR, 6.50; 95% CI, 1.39‐30.41; P = .017) as compared to the control group (n = 456). Placental disorders occurred more frequently in the CHD than in controls, but the increased risk showed only a borderline significance (4.5% vs 3.3%; aOR, 2.56; 95% CI, 0.99‐1.02; P = .046). There was a significantly higher risk of SGA in CHD than in controls (8.7% vs 3.9%; aOR, 3.37; 95% CI, 1.51‐7.51; P = .003). PTB occurred in 65/477 (13.6%) cases and in 39/447 (8.7%) controls (P = .022) (aOR, 2.17; 95% CI, 1.24‐3.81; P = .007). Conclusion Major CHD are significantly associated with the risk of PE, SGA and PTB.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Giorgione, V, Fesslova, V, Boveri, S, Candiani, M, Khalil, A, Cavoretto, P. Adverse perinatal outcome and placental abnormalities in pregnancies with major fetal congenital heart defects: A retrospective case‐control study. Prenatal Diagnosis. 2020; 40: 1390– 1397, which has been published in final form at https://doi.org/10.1002/pd.5770. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Keywords: Obstetrics & Reproductive Medicine, 1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Prenat Diagn
ISSN: 1097-0223
Language: eng
Dates:
DateEvent
20 October 2020Published
12 August 2020Published Online
16 June 2020Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
765274Horizon 2020UNSPECIFIED
PubMed ID: 32557693
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/112096
Publisher's version: https://doi.org/10.1002/pd.5770

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