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Cardiovascular Remodeling Experienced by Real-World, Unsupervised, Young Novice Marathon Runners.

D'Silva, A; Bhuva, AN; van Zalen, J; Bastiaenen, R; Abdel-Gadir, A; Jones, S; Nadarajan, N; Menacho Medina, KD; Ye, Y; Augusto, J; et al. D'Silva, A; Bhuva, AN; van Zalen, J; Bastiaenen, R; Abdel-Gadir, A; Jones, S; Nadarajan, N; Menacho Medina, KD; Ye, Y; Augusto, J; Treibel, TA; Rosmini, S; Ramlall, M; Scully, PR; Torlasco, C; Willis, J; Finocchiaro, G; Papatheodorou, E; Dhutia, H; Cole, D; Chis Ster, I; Hughes, AD; Sharma, R; Manisty, C; Lloyd, G; Moon, JC; Sharma, S (2020) Cardiovascular Remodeling Experienced by Real-World, Unsupervised, Young Novice Marathon Runners. Front Physiol, 11. p. 232. ISSN 1664-042X https://doi.org/10.3389/fphys.2020.00232
SGUL Authors: Chis Ster, Delizia Irina

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Abstract

Aims: Marathon running is a popular ambition in modern societies inclusive of non-athletes. Previous studies have highlighted concerning transient myocardial dysfunction and biomarker release immediately after the race. Whether this method of increasing physical activity is beneficial or harmful remains a matter of debate. We examine in detail the real-world cardiovascular remodeling response following competition in a first marathon. Methods: Sixty-eight novice marathon runners (36 men and 32 women) aged 30 ± 3 years were investigated 6 months before and 2 weeks after the 2016 London Marathon race in a prospective observational study. Evaluation included electrocardiography, cardiopulmonary exercise testing, echocardiography, and cardiovascular magnetic resonance imaging. Results: After 17 weeks unsupervised marathon training, runners revealed a symmetrical, eccentric remodeling response with 3-5% increases in left and right ventricular cavity sizes, respectively. Blood pressure (BP) fell by 4/2 mmHg (P < 0.01) with reduction in arterial stiffness, despite only 11% demonstrating a clinically meaningful improvement in peak oxygen consumption with an overall non-significant 0.4 ml/min/kg increase in peak oxygen consumption (P = 0.14). Conclusion: In the absence of supervised training, exercise-induced cardiovascular remodeling in real-world novice marathon runners is more modest than previously described and occurs even without improvement in cardiorespiratory fitness. The responses are similar in men and women, who experience a beneficial BP reduction and no evidence of myocardial fibrosis or persistent edema, when achieving average finishing times.

Item Type: Article
Additional Information: Copyright © 2020 D’Silva, Bhuva, van Zalen, Bastiaenen, Abdel-Gadir, Jones, Nadarajan, Menacho Medina, Ye, Augusto, Treibel, Rosmini, Ramlall, Scully, Torlasco, Willis, Finocchiaro, Papatheodorou, Dhutia, Cole, Chis Ster, Hughes, Sharma, Manisty, Lloyd, Moon and Sharma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: athlete’s heart, cardiorespiratory fitness, cardiovascular remodeling, endurance exercise, marathon, sports cardiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Front Physiol
ISSN: 1664-042X
Language: eng
Dates:
DateEvent
18 March 2020Published
28 February 2020Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
FS/15/27/31465British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
FS/16/46/32187British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PubMed ID: 32256389
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111852
Publisher's version: https://doi.org/10.3389/fphys.2020.00232

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