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A three year descriptive study of early onset neonatal sepsis in a refugee population on the Thailand Myanmar border.

Turner, C; Turner, P; Hoogenboom, G; Aye Mya Thein, N; McGready, R; Phakaudom, K; De Zoysa, A; Efstratiou, A; Heath, PT; Nosten, F (2013) A three year descriptive study of early onset neonatal sepsis in a refugee population on the Thailand Myanmar border. BMC Infect Dis, 13. p. 601. ISSN 1471-2334 https://doi.org/10.1186/1471-2334-13-601
SGUL Authors: Heath, Paul Trafford

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Abstract

BACKGROUND: Each year an estimated four million neonates die, the majority in the first week of life. One of the major causes of death is sepsis. Proving the incidence and aetiology of neonatal sepsis is difficult, particularly in resource poor settings where the majority of the deaths occur. METHODS: We conducted a three year observational study of clinically diagnosed early onset (<7 days of age) neonatal sepsis (EONS) in infants born to mothers following antenatal care at the Shoklo Malaria Research Unit clinic in Maela camp for displaced persons on the Thailand-Myanmar border. Episodes of EONS were identified using a clinical case definition. Conventional and molecular microbiological techniques were employed in order to determine underlying aetiology. RESULTS: From April 2009 until April 2012, 187 infants had clinical signs of EONS, giving an incidence rate of 44.8 per 1000 live births (95% CI 38.7-51.5). One blood culture was positive for Escherichia coli, E. coli was detected in the cerebrospinal fluid specimen in this infant, and in an additional two infants, by PCR. Therefore, the incidence of bacteriologically proven EONS was 0.7 per 1000 live births (95% CI 0.1-2.1). No infants enrolled in study died as a direct result of EONS. CONCLUSION: A low incidence of bacteriologically proven EONS was seen in this study, despite a high incidence of clinically diagnosed EONS. The use of molecular diagnostics and nonspecific markers of infection need to be studied in resource poor settings to improve the diagnosis of EONS and rationalise antibiotic use.

Item Type: Article
Additional Information: © 2013 Turner et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Escherichia coli, Escherichia coli Infections, Female, Humans, Incidence, Infant, Newborn, Infant, Newborn, Diseases, Male, Myanmar, Refugees, Sepsis, Thailand, Humans, Escherichia coli, Escherichia coli Infections, Sepsis, Infant, Newborn, Diseases, Incidence, Infant, Newborn, Refugees, Myanmar, Thailand, Female, Male, Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, INFECTIOUS DISEASES, B STREPTOCOCCAL DISEASE, YOUNG INFANTS, DEVELOPING-COUNTRIES, PREGNANT-WOMEN, RISK-FACTORS, INFECTIONS, PREVENTION, BURDEN, MALAWI, KENYA, 0605 Microbiology, 1103 Clinical Sciences, 1108 Medical Microbiology, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: BMC Infect Dis
ISSN: 1471-2334
Language: eng
Dates:
DateEvent
21 December 2013Published
18 December 2013Accepted
Publisher License: Creative Commons: Attribution 2.0
Projects:
Project IDFunderFunder ID
089275Wellcome Trusthttp://dx.doi.org/10.13039/100004440
077166/Z/05Wellcome Trusthttp://dx.doi.org/10.13039/100004440
083735/Z/07/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 24359288
Web of Science ID: WOS:000329375000002
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111332
Publisher's version: https://doi.org/10.1186/1471-2334-13-601

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