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Looking to the future of zebrafish as a model to understand the genetic basis of eye disease

Cavodeassi, F; Wilson, S (2019) Looking to the future of zebrafish as a model to understand the genetic basis of eye disease. HUMAN GENETICS, 138 (8-9). pp. 993-1000. ISSN 0340-6717 https://doi.org/10.1007/s00439-019-02055-z
SGUL Authors: Cavodeassi, Florencia

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Abstract

In this brief commentary, we provide some of our thoughts and opinions on the current and future use of zebrafish to model human eye disease, dissect pathological progression and advance in our understanding of the genetic bases of microphthalmia, andophthalmia and coloboma (MAC) in humans. We provide some background on eye formation in fish and conservation and divergence across vertebrates in this process, discuss different approaches for manipulating gene function and speculate on future research areas where we think research using fish may prove to be particularly effective.

Item Type: Article
Additional Information: © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: 0604 Genetics, 1104 Complementary And Alternative Medicine, 1114 Paediatrics And Reproductive Medicine, Genetics & Heredity
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: HUMAN GENETICS
ISSN: 0340-6717
Dates:
DateEvent
September 2019Published
17 August 2019Published Online
31 July 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
UNSPECIFIEDMedical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIEDWellcome Trusthttp://dx.doi.org/10.13039/100004440
UNSPECIFIEDFight for Sighthttp://dx.doi.org/10.13039/100002089
URI: https://openaccess.sgul.ac.uk/id/eprint/111117
Publisher's version: https://doi.org/10.1007/s00439-019-02055-z

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