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Two-Dimensional Echocardiography Estimates of Fetal Ventricular Mass throughout Gestation.

Aye, CYL; Lewandowski, AJ; Ohuma, EO; Upton, R; Packham, A; Kenworthy, Y; Roseman, F; Norris, T; Molloholli, M; Wanyonyi, S; et al. Aye, CYL; Lewandowski, AJ; Ohuma, EO; Upton, R; Packham, A; Kenworthy, Y; Roseman, F; Norris, T; Molloholli, M; Wanyonyi, S; Papageorghiou, AT; Leeson, P (2018) Two-Dimensional Echocardiography Estimates of Fetal Ventricular Mass throughout Gestation. Fetal Diagn Ther, 44 (1). pp. 18-27. ISSN 1421-9964 https://doi.org/10.1159/000477964
SGUL Authors: Papageorghiou, Aris

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Abstract

BACKGROUND: Two-dimensional (2D) ultrasound quality has improved in recent years. Quantification of cardiac dimensions is important to screen and monitor certain fetal conditions. We assessed the feasibility and reproducibility of fetal ventricular measures using 2D echocardiography, reported normal ranges in our cohort, and compared estimates to other modalities. METHODS: Mass and end-diastolic volume were estimated by manual contouring in the four-chamber view using TomTec Image Arena 4.6 in end diastole. Nomograms were created from smoothed centiles of measures, constructed using fractional polynomials after log transformation. The results were compared to those of previous studies using other modalities. RESULTS: A total of 294 scans from 146 fetuses from 15+0 to 41+6 weeks of gestation were included. Seven percent of scans were unanalysable and intraobserver variability was good (intraclass correlation coefficients for left and right ventricular mass 0.97 [0.87-0.99] and 0.99 [0.95-1.0], respectively). Mass and volume increased exponentially, showing good agreement with 3D mass estimates up to 28 weeks of gestation, after which our measurements were in better agreement with neonatal cardiac magnetic resonance imaging. There was good agreement with 4D volume estimates for the left ventricle. CONCLUSION: Current state-of-the-art 2D echocardiography platforms provide accurate, feasible, and reproducible fetal ventricular measures across gestation, and in certain circumstances may be the modality of choice.

Item Type: Article
Additional Information: This is the peer-reviewed but unedited manuscript version of the following article: Fetal Diagn Ther 2018;44:18–27 (DOI: 10.1159/000477964). The final, published version is available at https://www.karger.com/?doi=10.1159/000477964.
Keywords: Fetal cardiac mass, Offline gating, Semi-automated measures, Two-dimensional echocardiography, Ventricular mass estimates, Volume estimates, Adult, Echocardiography, Feasibility Studies, Female, Fetal Heart, Heart Ventricles, Humans, Pregnancy, Reference Values, Reproducibility of Results, Ultrasonography, Prenatal, Fetal Heart, Heart Ventricles, Humans, Echocardiography, Ultrasonography, Prenatal, Feasibility Studies, Reproducibility of Results, Pregnancy, Reference Values, Adult, Female, Fetal cardiac mass, Two-dimensional echocardiography, Ventricular mass estimates, Volume estimates, Offline gating, Semi-automated measures, Fetal cardiac mass, Offline gating, Semi-automated measures, Two-dimensional echocardiography, Ventricular mass estimates, Volume estimates, 1114 Paediatrics And Reproductive Medicine, Obstetrics & Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Fetal Diagn Ther
ISSN: 1421-9964
Language: eng
Dates:
DateEvent
July 2018Published
12 August 2017Published Online
30 May 2017Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
FS/11/65/28865British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PG/13/58/30397British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PubMed ID: 28803252
Web of Science ID: WOS:000440096900003
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111072
Publisher's version: https://doi.org/10.1159/000477964

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